1A5B
CRYO-CRYSTALLOGRAPHY OF A TRUE SUBSTRATE, INDOLE-3-GLYCEROL PHOSPHATE, BOUND TO A MUTANT (ALPHA D60N) TRYPTOPHAN SYNTHASE ALPHA2BETA2 COMPLEX REVEALS THE CORRECT ORIENTATION OF ACTIVE SITE ALPHA GLU 49
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | TRYPTOPHAN SYNTHASE (ALPHA CHAIN) | polymer | 268 | 28697.8 | 1 | UniProt (P00929) Pfam (PF00290) In PDB | Salmonella typhimurium | |
| 2 | B | TRYPTOPHAN SYNTHASE (BETA CHAIN) | polymer | 397 | 42973.0 | 1 | UniProt (P0A2K1) Pfam (PF00291) In PDB | Salmonella typhimurium | |
| 3 | A | INDOLE-3-GLYCEROL PHOSPHATE | non-polymer | 287.2 | 1 | Chemie (IGP) | |||
| 4 | B | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 5 | B | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 1 | Chemie (PLP) | |||
| 6 | water | water | 18.0 | 337 | Chemie (HOH) |
Sequence modifications
A: 1 - 268 (UniProt: P00929)
B: 2 - 397 (UniProt: P0A2K1)
| PDB | External Database | Details |
|---|---|---|
| Asn 60 | Asp 60 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Leu 396 | Glu 395 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71670.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 573.4 | |
| All* | Total formula weight | 72244.3 |
