1CW2

CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-HYDROXYPHENYLSULFINYL)-BUTYLPHOSPHONIC ACID

Summary for 1CW2

Entry DOI	10.2210/pdb1cw2/pdb
Related	1C29 1C8V 1C9D
Descriptor	TRYPTOPHAN SYNTHASE (ALPHA CHAIN), TRYPTOPHAN SYNTHASE (BETA CHAIN), 4-(2-HYDROXYPHENYLSULFINYL)-BUTYLPHOSPHONIC ACID, ... (6 entities in total)
Functional Keywords	8-fold alpha-beta barrel, enzyme-inhibitor complex, lyase
Biological source	Salmonella typhimurium More
Total number of polymer chains	2
Total formula weight	72236.19
Authors	Sachpatzidis, A.,Dealwis, C.,Lubetsky, J.B.,Liang, P.H.,Anderson, K.S.,Lolis, E. (deposition date: 1999-08-25, release date: 1999-12-21, Last modification date: 2024-03-13)
Primary citation	Sachpatzidis, A.,Dealwis, C.,Lubetsky, J.B.,Liang, P.H.,Anderson, K.S.,Lolis, E. Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase. Biochemistry, 38:12665-12674, 1999 Cited by PubMed: 10504236 DOI: 10.1021/bi9907734 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation