1C8V
CRYSTAL STRUCTURE OF THE COMPLEX OF BACTERIAL TRYPTOPHAN SYNTHASE WITH THE TRANSITION STATE ANALOGUE INHIBITOR 4-(2-HYDROXYPHENYLTHIO)-BUTYLPHOSPHONIC ACID
Summary for 1C8V
Entry DOI | 10.2210/pdb1c8v/pdb |
Related | 1C29 |
Descriptor | TRYPTOPHAN SYNTHASE; ALPHA CHAIN, TRYPTOPHAN SYNTHASE; BETA CHAIN, 4-(2-HYDROXYPHENYLTHIO)-1-BUTENYLPHOSPHONIC ACID, ... (6 entities in total) |
Functional Keywords | 8-fold alpha-beta barrel, enzyme-inhibitor complex, lyase |
Biological source | Salmonella typhimurium More |
Total number of polymer chains | 2 |
Total formula weight | 72218.17 |
Authors | Sachpatzidis, A.,Dealwis, C.,Lubetsky, J.B.,Liang, P.H.,Anderson, K.S.,Lolis, E. (deposition date: 1999-07-30, release date: 2000-01-13, Last modification date: 2024-03-13) |
Primary citation | Sachpatzidis, A.,Dealwis, C.,Lubetsky, J.B.,Liang, P.H.,Anderson, K.S.,Lolis, E. Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase. Biochemistry, 38:12665-12674, 1999 Cited by PubMed: 10504236DOI: 10.1021/bi9907734 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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