1A5A

CRYO-CRYSTALLOGRAPHY OF A TRUE SUBSTRATE, INDOLE-3-GLYCEROL PHOSPHATE, BOUND TO A MUTANT (ALPHAD60N) TRYPTOPHAN SYNTHASE ALPHA2BETA2 COMPLEX REVEALS THE CORRECT ORIENTATION OF ACTIVE SITE ALPHA GLU 49

Summary for 1A5A

Entry DOI	10.2210/pdb1a5a/pdb
Descriptor	TRYPTOPHAN SYNTHASE (ALPHA CHAIN), TRYPTOPHAN SYNTHASE (BETA CHAIN), POTASSIUM ION, ... (5 entities in total)
Functional Keywords	carbon-oxygen lyase, mutation at position 60 (asp --> asn) in the a-subunit, lyase
Biological source	Salmonella typhimurium More
Total number of polymer chains	2
Total formula weight	71957.09
Authors	Rhee, S.,Miles, E.W.,Davies, D.R. (deposition date: 1998-02-12, release date: 1998-05-27, Last modification date: 2021-11-03)
Primary citation	Rhee, S.,Miles, E.W.,Davies, D.R. Cryo-crystallography of a true substrate, indole-3-glycerol phosphate, bound to a mutant (alphaD60N) tryptophan synthase alpha2beta2 complex reveals the correct orientation of active site alphaGlu49. J.Biol.Chem., 273:8553-8555, 1998 Cited by PubMed: 9535826 DOI: 10.1074/jbc.273.15.8553 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation