2J6M

Crystal structure of EGFR kinase domain in complex with AEE788

2J6M の概要

• エントリーDOI: 10.2210/pdb2j6m/pdb
• 関連するPDBエントリー: 1DNQ 1DNR 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2GS2 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E 2J5F
• 分子名称: EPIDERMAL GROWTH FACTOR RECEPTOR, 6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE (3 entities in total)
• 機能のキーワード: cell cycle, atp-binding, transferase, polymorphism, nucleotide-binding, alternative splicing, tyrosine-protein kinase, epidermal growth factor, ubl conjugation, phosphorylation, disease mutation, glycoprotein, anti-oncogene, transmembrane, egfr, kinase, aee788, membrane, receptor, wild-type
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37744.71

構造登録者

Yun, C.-H.,Boggon, T.J.,Li, Y.,Woo, S.,Greulich, H.,Meyerson, M.,Eck, M.J. (登録日: 2006-09-29, 公開日: 2007-04-03, 最終更新日: 2023-12-13)

• 主引用文献: Yun, C.-H.,Boggon, T.J.,Li, Y.,Woo, S.,Greulich, H.,Meyerson, M.,Eck, M.J.; Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity; Cancer Cell, 11:217-, 2007; PubMed: 17349580; DOI: 10.1016/J.CCR.2006.12.017

実験手法

X-RAY DIFFRACTION (3.1 Å)