2J5F

Crystal structure of EGFR kinase domain in complex with an irreversible inhibitor 34-jab

2J5F の概要

• エントリーDOI: 10.2210/pdb2j5f/pdb
• 関連するPDBエントリー: 1DNQ 1DNR 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2GS2 2GS7 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ 2J5E
• 分子名称: EPIDERMAL GROWTH FACTOR RECEPTOR, N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE (3 entities in total)
• 機能のキーワード: cell cycle, atp-binding, transferase, polymorphism, irreversible inhibitor, tyrosine-protein kinase, egfr, kinase, 34-jab, membrane, receptor, wild-type, epidermal growth factor, anti-oncogene, transmembrane, nucleotide-binding, alternative splicing, ubl conjugation, phosphorylation, disease mutation, glycoprotein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37673.34

構造登録者

Yun, C.-H.,Eck, M.J. (登録日: 2006-09-14, 公開日: 2007-02-27, 最終更新日: 2023-12-13)

• 主引用文献: Blair, J.A.,Rauh, D.,Kung, C.,Yun, C.-H.,Fan, Q.-W.,Rode, H.,Zhang, C.,Eck, M.J.,Weiss, W.A.,Shokat, K.M.; Structure-Guided Development of Affinity Probes for Tyrosine Kinases Using Chemical Genetics.; Nat.Chem.Biol., 3:229-, 2007; PubMed: 17334377; DOI: 10.1038/NCHEMBIO866

実験手法

X-RAY DIFFRACTION (3 Å)