2J4A

Human Thyroid hormone receptor beta ligand binding domain in complex with KB131084

2J4A の概要

• エントリーDOI: 10.2210/pdb2j4a/pdb
• 関連するPDBエントリー: 1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2H6W 2NLL
• 分子名称: THYROID HORMONE RECEPTOR BETA-1, 3,5-DIBROMO-4-(3-ISOPROPYL-PHENOXY)BENZOIC ACID (3 entities in total)
• 機能のキーワード: nuclear protein, disease mutation, nuclear receptor, zinc, receptor, deafness, zinc-finger, dna-binding, transcription regulation, transcription, alternative splicing, ligand binding domain, polymorphism, metal-binding
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29013.20

構造登録者

Farnegardh, M. (登録日: 2006-08-28, 公開日: 2007-09-25, 最終更新日: 2024-05-08)

主引用文献

Koehler, K.,Gordon, S.,Brandt, P.,Carlsson, B.,Backsbro-Saedi, A.,Apelqvist, T.,Agback, P.,Grover, G.J.,Nelson, W.,Grynfarb, M.,Farnegardh, M.,Rehnmark, S.,Malm, J.
Thyroid Receptor Ligands. 6. A High Affinity "Direct Antagonist" Selective for the Thyroid Hormone Receptor.
J.Med.Chem., 49:6635-, 2006

PubMed Abstract: A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.

PubMed: 17154490
DOI: 10.1021/JM060521I

実験手法

X-RAY DIFFRACTION (2.2 Å)