2ITW

Crystal structure of EGFR kinase domain in complex with AFN941

Summary for 2ITW

Entry DOI	10.2210/pdb2itw/pdb
Related	1DNQ 1DNR 1IVO 1M14 1M17 1MOX 1NQL 1XKK 1YY9 1Z9I 2ITN 2ITO 2ITP 2ITQ 2ITT 2ITU 2ITV 2ITX 2ITY 2ITZ
Descriptor	EPIDERMAL GROWTH FACTOR RECEPTOR, 1,2,3,4-Tetrahydrogen Staurosporine (3 entities in total)
Functional Keywords	receptor, cell cycle, atp-binding, transferase, transmembrane, phosphorylation, disease mutation, polymorphism, glycoprotein, anti-oncogene, nucleotide-binding, alternative splicing, afn941, egfr, kinase, staurosporine, membrane, tyrosine-protein kinase, epidermal growth factor
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains	1
Total formula weight	37772.68
Authors	Yun, C.-H.,Boggon, T.J.,Li, Y.,Woo, S.,Greulich, H.,Meyerson, M.,Eck, M.J. (deposition date: 2006-05-25, release date: 2007-04-03, Last modification date: 2023-12-13)
Primary citation	Yun, C.-H.,Boggon, T.J.,Li, Y.,Woo, S.,Greulich, H.,Meyerson, M.,Eck, M.J. Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity Cancer Cell, 11:217-, 2007 Cited by PubMed: 17349580 DOI: 10.1016/J.CCR.2006.12.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.88 Å)

Structure validation