2GTW

Human Class I MHC HLA-A2 in complex with the nonameric Melan-A/MART-1(27-35) peptide having A27L substitution

Summary for 2GTW
Related1JF1 1JHT 2GT9 2GTZ 2GUO
DescriptorHLA-A*0201 heavy chain, Beta-2-microglobulin, octapeptide from Melan-A/MART-1, ... (7 entities in total)
Functional Keywordsmelan-a/mart-1 peptide, nonapeptide, mhc class i, hla-a2, a27l mutation, melanoma, cancer vaccines, immune system
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted: P61769
Endoplasmic reticulum membrane; Single-pass type III membrane protein: Q16655
Total number of polymer chains6
Total formula weight89869.79
Authors
Borbulevych, O.Y.,Baker, B.M. (deposition date: 2006-04-28, release date: 2007-06-12, Last modification date: 2011-07-13)
Primary citationBaker, B.M.,Baxter, T.K.,Borbulevych, O.Y.,Insaidoo, F.K.,Johnson, L.A.,Powell, D.J.,Restifo, N.P.
Structures of MART-1(26/27-35) Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition
J.Mol.Biol., 372:1123-1136, 2007
PubMed: 17719062
DOI: 110.1016/j.jmb.2007.07.025
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.548 Å)
Structure validation
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PDB entries from 2021-06-09