2GTW
Human Class I MHC HLA-A2 in complex with the nonameric Melan-A/MART-1(27-35) peptide having A27L substitution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | HLA-A*0201 heavy chain | polymer | 275 | 31854.2 | 2 | UniProt (Q9TQH5) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) | Homo sapiens (human) | HLA class I histocompatibility antigen, A-2 alpha chain; MHC class I antigen A*2 |
| 2 | B, E (B, E) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 2 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | Beta-2-microglobulin variant pI 5.3 |
| 3 | C, F (C, F) | octapeptide from Melan-A/MART-1 | polymer | 9 | 856.1 | 2 | UniProt (Q16655) | Melanoma antigen recognized by T-cells 1 | |
| 4 | G, H, L, N, O (A, B, D) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 5 | I, J, M, P (A, B, D) | FORMIC ACID | non-polymer | 46.0 | 4 | Chemie (FMT) | |||
| 6 | K, Q (B, E) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 7 | R, S, T, U, V... (A, B, C, D, E...) | water | water | 18.0 | 672 | Chemie (HOH) |
Sequence modifications
B, E: 1 - 99 (UniProt: P61769)
C, F: 2 - 9 (UniProt: Q16655)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Leu 1 | Ala 27 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 89179.2 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 690.5 | |
| All* | Total formula weight | 89869.8 |
