Human Class I MHC HLA-A2 in complex with the native nonameric Melan-A/MART-1(27-35) peptide

Summary for 2GUO
Related1JFI 1JHT 2GT9 2GTW 2GTZ
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Peptide, ... (6 entities in total)
Functional Keywordsmelan-a/mart-1 peptide, nonapeptide, mhc class i, hla-a2, melanoma, cancer vaccines, immune system
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P61769
Endoplasmic reticulum membrane; Single-pass type III membrane protein: Q16655
Total number of polymer chains6
Total formula weight89486.45
Borbulevych, O.Y.,Baker, B.M. (deposition date: 2006-05-01, release date: 2007-06-12, Last modification date: 2011-07-13)
Primary citationBaker, B.M.,Baxter, T.K.,Borbulevych, O.Y.,Insaidoo, F.K.,Johnson, L.A.,Powell, D.J.,Restifo, N.P.
Structures of MART-1(26/27-35) Peptide/HLA-A2 Complexes Reveal a Remarkable Disconnect between Antigen Structural Homology and T Cell Recognition
J.Mol.Biol., 372:1123-1136, 2007
PubMed: 17719062
DOI: 110.1016/j.jmb.2007.07.025
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-09