2FXS
Yeast HSP82 in complex with the novel HSP90 Inhibitor Radamide
Summary for 2FXS
Entry DOI | 10.2210/pdb2fxs/pdb |
Related | 1A4H 1BGQ 1QY8 1U0Z 1ZWH 2EXL 2FYP |
Descriptor | ATP-dependent molecular chaperone HSP82, METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | hsp82, hsp90, grp94, htpg, chaperone, ligand, radicicol, geldanamycin, radester |
Biological source | Saccharomyces cerevisiae (baker's yeast) |
Cellular location | Cytoplasm: P02829 |
Total number of polymer chains | 1 |
Total formula weight | 27917.03 |
Authors | Immormino, R.M.,Gewirth, D.T. (deposition date: 2006-02-06, release date: 2007-02-06, Last modification date: 2023-08-30) |
Primary citation | Immormino, R.M.,Metzger, L.E.,Reardon, P.N.,Dollins, D.E.,Blagg, B.S.,Gewirth, D.T. Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design. J.Mol.Biol., 388:1033-1042, 2009 Cited by PubMed: 19361515DOI: 10.1016/j.jmb.2009.03.071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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