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2BT0

Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design

Summary for 2BT0
Entry DOI10.2210/pdb2bt0/pdb
Related1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM
DescriptorHEAT SHOCK PROTEIN HSP90-ALPHA, 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL (3 entities in total)
Functional Keywordsatp-binding, chaperone, heat shock, phosphorylation
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus : P07900
Total number of polymer chains2
Total formula weight53645.92
Authors
Dymock, B.W.,Barril, X.,Brough, P.A.,Cansfield, J.E.,Massey, A.,McDonald, E.,Hubbard, R.E.,Surgenor, A.,Roughley, S.D.,Webb, P.,Workman, P.,Wright, L.,Drysdale, M.J. (deposition date: 2005-05-24, release date: 2005-06-02, Last modification date: 2023-12-13)
Primary citationDymock, B.W.,Barril, X.,Brough, P.A.,Cansfield, J.E.,Massey, A.,McDonald, E.,Hubbard, R.E.,Surgenor, A.,Roughley, S.D.,Webb, P.,Workman, P.,Wright, L.,Drysdale, M.J.
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.
J. Med. Chem., 48:4212-4215, 2005
Cited by
PubMed: 15974572
DOI: 10.1021/jm050355z
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

數據於2024-03-27公開中

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