2BT0

Novel, potent small molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design

2BT0 の概要

• エントリーDOI: 10.2210/pdb2bt0/pdb
• 関連するPDBエントリー: 1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM
• 分子名称: HEAT SHOCK PROTEIN HSP90-ALPHA, 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL (3 entities in total)
• 機能のキーワード: atp-binding, chaperone, heat shock, phosphorylation
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus : P07900
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53645.92

構造登録者

Dymock, B.W.,Barril, X.,Brough, P.A.,Cansfield, J.E.,Massey, A.,McDonald, E.,Hubbard, R.E.,Surgenor, A.,Roughley, S.D.,Webb, P.,Workman, P.,Wright, L.,Drysdale, M.J. (登録日: 2005-05-24, 公開日: 2005-06-02, 最終更新日: 2023-12-13)

• 主引用文献: Dymock, B.W.,Barril, X.,Brough, P.A.,Cansfield, J.E.,Massey, A.,McDonald, E.,Hubbard, R.E.,Surgenor, A.,Roughley, S.D.,Webb, P.,Workman, P.,Wright, L.,Drysdale, M.J.; Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.; J. Med. Chem., 48:4212-4215, 2005; PubMed: 15974572; DOI: 10.1021/jm050355z

実験手法

X-RAY DIFFRACTION (1.9 Å)