2B1I

crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase

Summary for 2B1I

• Entry DOI: 10.2210/pdb2b1i/pdb
• Related: 1G8M 1M9N 1OZ0 1PKX 1PL0 1THZ 2b0w 2b1g
• Descriptor: Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, [3,4-DIHYDROXY-5R-(2,2,4-TRIOXO-1,2R,3S,4R-TETRAHYDRO-2L6-IMIDAZO[4,5-C][1,2,6]THIADIAZIN-7-YL)TETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN PHOSPHATE, ... (4 entities in total)
• Functional Keywords: atic, impch, structure-base, transition state analogue, inhibitor, transferase, hydrolase
• Biological source: Gallus gallus (chicken)
• Total number of polymer chains: 2
• Total formula weight: 130674.64

Authors

Xu, L.,Chong, Y.,Hwang, I.,D'Onofrio, A.,Amore, K.,Beardsley, G.P.,Li, C.,Olson, A.J.,Boger, D.L.,Wilson, I.A. (deposition date: 2005-09-15, release date: 2006-11-21, Last modification date: 2023-08-23)

• Primary citation: Xu, L.,Chong, Y.,Hwang, I.,D'Onofrio, A.,Amore, K.,Beardsley, G.P.,Li, C.,Olson, A.J.,Boger, D.L.,Wilson, I.A.; Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase.; J.Biol.Chem., 282:13033-13046, 2007; PubMed: 17324932; DOI: 10.1074/jbc.M607293200

Experimental method

X-RAY DIFFRACTION (2.02 Å)