1ZPK

Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2

1ZPK の概要

• エントリーDOI: 10.2210/pdb1zpk/pdb
• 関連するPDBエントリー: 1FQX 1IIQ 1LZQ 1M0B 1Z8C 1ZBG 1ZJ7 1ZLF 1ZSF 1ZSR
• 関連するBIRD辞書のPRD_ID: PRD_000385
• 分子名称: PROTEASE RETROPEPSIN, N-{(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: hiv, protease, peptidomimetic inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22554.02

構造登録者

Duskova, J.,Skalova, T.,Dohnalek, J.,Petrokova, H.,Hasek, J. (登録日: 2005-05-17, 公開日: 2006-04-25, 最終更新日: 2023-08-23)

• 主引用文献: Duskova, J.,Skalova, T.,Dohnalek, J.,Petrokova, H.,Hasek, J.; Mutational Study of Pseudopeptide Inhibitor Binding to HIV-1 Protease; Analysis of Four X-ray Structures; To be Published,

実験手法

X-RAY DIFFRACTION (1.65 Å)