1X86

Crystal Structure of the DH/PH domains of Leukemia-associated RhoGEF in complex with RhoA

Summary for 1X86

• Entry DOI: 10.2210/pdb1x86/pdb
• Related: 1TXD
• Descriptor: Rho guanine nucleotide exchange factor 12, Transforming protein RhoA, PHOSPHATE ION (3 entities in total)
• Functional Keywords: helical bundle (dh), beta sandwich (ph), alpha/beta (rhoa), signaling protein-membrane protein complex, signaling protein/membrane protein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm (Probable): Q9NZN5; Cell membrane; Lipid-anchor; Cytoplasmic side: P61586
• Total number of polymer chains: 8
• Total formula weight: 267687.05

Authors

Kristelly, R.,Gao, G.,Tesmer, J.J. (deposition date: 2004-08-17, release date: 2004-09-21, Last modification date: 2024-02-14)

• Primary citation: Kristelly, R.,Gao, G.,Tesmer, J.J.; Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.; J.Biol.Chem., 279:47352-47362, 2004; PubMed: 15331592; DOI: 10.1074/jbc.M406056200

Experimental method

X-RAY DIFFRACTION (3.22 Å)