1TMM

Crystal structure of ternary complex of E.coli HPPK(W89A) with MGAMPCPP and 6-Hydroxymethylpterin

1TMM の概要

• エントリーDOI: 10.2210/pdb1tmm/pdb
• 関連するPDBエントリー: 1CBK 1DY3 1EQ0 1EQM 1EX8 1F9H 1F9Y 1G4C 1HKA 1HQ2 1IM6 1KBR 1Q0N 1RB0 1RTZ 1RU1 1RU2 1TMJ
• 分子名称: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, MAGNESIUM ION, CHLORIDE ION, ... (8 entities in total)
• 機能のキーワード: pyrophosphokinase, pyrophosphoryl transfer, catalytic mechanism, folate, hppk, pterin, 6-hydroxymethyl-7, 8-dihydropterin, 6-hydroxymethylpterin, ternary complex, substrate specificity, product release, antimicrobial agent, drug design, transferase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37747.79

構造登録者

Blaszczyk, J.,Li, Y.,Wu, Y.,Shi, G.,Ji, X.,Yan, H. (登録日: 2004-06-10, 公開日: 2005-06-21, 最終更新日: 2024-03-13)

• 主引用文献: Li, Y.,Blaszczyk, J.,Wu, Y.,Shi, G.,Ji, X.,Yan, H.; Is the Critical Role of Loop 3 of Escherichia coli 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase in Catalysis Due to Loop-3 Residues Arginine-84 and Tryptophan-89? Site-Directed Mutagenesis, Biochemical, and Crystallographic Studies.; Biochemistry, 44:8590-8599, 2005; PubMed: 15952765; DOI: 10.1021/bi0503495

実験手法

X-RAY DIFFRACTION (1.25 Å)