1THZ

Crystal Structure of Avian AICAR Transformylase in Complex with a Novel Inhibitor Identified by Virtual Ligand Screening

1THZ の概要

• エントリーDOI: 10.2210/pdb1thz/pdb
• 関連するPDBエントリー: 1G8M 1M9N 1OZ0 1P4R 1PKX 1PL0
• 分子名称: Bifunctional purine biosynthesis protein PURH, POTASSIUM ION, 2-{(E)-[5-HYDROXY-3-METHYL-1-(2-METHYL-4-SULFOPHENYL)-1H-PYRAZOL-4-YL]DIAZENYL}-4-SULFOBENZOIC ACID, ... (4 entities in total)
• 機能のキーワード: atic, virtual ligand screening, purine biosynthesis, cancer target, transferase, hydrolase
• 由来する生物種: Gallus gallus (chicken)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 130066.54

構造登録者

Xu, L.,Li, C.,Olson, A.J.,Wilson, I.A. (登録日: 2004-06-01, 公開日: 2004-09-07, 最終更新日: 2023-08-23)

• 主引用文献: Xu, L.,Li, C.,Olson, A.J.,Wilson, I.A.; Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening.; J.Biol.Chem., 279:50555-50565, 2004; PubMed: 15355974; DOI: 10.1074/jbc.M406801200

実験手法

X-RAY DIFFRACTION (1.8 Å)