1S64
Rat protein geranylgeranyltransferase type-I complexed with L-778,123 and a sulfate anion
Summary for 1S64
Entry DOI | 10.2210/pdb1s64/pdb |
Related | 1JCQ 1LD7 1N4P 1N4Q 1O5M 1S63 |
Descriptor | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Geranylgeranyl transferase type I beta subunit, ZINC ION, ... (8 entities in total) |
Functional Keywords | l-778, 123, protein geranylgeranyltransferase type-i, protein prenylation, lipid modification, drug, transferase |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 12 |
Total formula weight | 524280.54 |
Authors | Reid, T.S.,Long, S.B.,Beese, L.S. (deposition date: 2004-01-22, release date: 2004-07-27, Last modification date: 2023-08-23) |
Primary citation | Reid, T.S.,Long, S.B.,Beese, L.S. Crystallographic Analysis Reveals that Anticancer Clinical Candidate L-778,123 Inhibits Protein Farnesyltransferase and Geranylgeranyltransferase-I by Different Binding Modes. Biochemistry, 43:9000-9008, 2004 Cited by PubMed: 15248757DOI: 10.1021/bi049280b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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