1S63
Human protein farnesyltransferase complexed with L-778,123 and FPP
Summary for 1S63
Entry DOI | 10.2210/pdb1s63/pdb |
Related | 1D8D 1FT1 1LD7 1LD8 1N4Q 1O5M 1S64 |
Related PRD ID | PRD_900003 |
Descriptor | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | farnesyltransferase, ftase, geranylgeranyltransferase, cancer, caax, fti, inhibitor, ras, lipid modification, protein prenylation, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 94883.16 |
Authors | Long, S.B.,Casey, P.J.,Beese, L.S. (deposition date: 2004-01-22, release date: 2004-07-27, Last modification date: 2023-08-23) |
Primary citation | Reid, T.S.,Long, S.B.,Beese, L.S. Crystallographic Analysis Reveals that Anticancer Clinical Candidate L-778,123 Inhibits Protein Farnesyltransferase and Geranylgeranyltransferase-I by Different Binding Modes. Biochemistry, 43:9000-9008, 2004 Cited by PubMed: 15248757DOI: 10.1021/bi049280b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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