1S63

Human protein farnesyltransferase complexed with L-778,123 and FPP

Summary for 1S63

Entry DOI	10.2210/pdb1s63/pdb
Related	1D8D 1FT1 1LD7 1LD8 1N4Q 1O5M 1S64
Related PRD ID	PRD_900003
Descriptor	Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (7 entities in total)
Functional Keywords	farnesyltransferase, ftase, geranylgeranyltransferase, cancer, caax, fti, inhibitor, ras, lipid modification, protein prenylation, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	94883.16
Authors	Long, S.B.,Casey, P.J.,Beese, L.S. (deposition date: 2004-01-22, release date: 2004-07-27, Last modification date: 2023-08-23)
Primary citation	Reid, T.S.,Long, S.B.,Beese, L.S. Crystallographic Analysis Reveals that Anticancer Clinical Candidate L-778,123 Inhibits Protein Farnesyltransferase and Geranylgeranyltransferase-I by Different Binding Modes. Biochemistry, 43:9000-9008, 2004 Cited by PubMed: 15248757 DOI: 10.1021/bi049280b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation