1LD7

Co-crystal structure of Human Farnesyltransferase with farnesyldiphosphate and inhibitor compound 66

Summary for 1LD7

• Entry DOI: 10.2210/pdb1ld7/pdb
• Related: 1JCQ 1LD8
• Related PRD ID: PRD_900003
• Descriptor: protein farnesyltransferase alpha subunit, protein farnesyltransferase beta subunit, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: alpha-alpha barrel, inhibitor, ftase, pftase, fpp, caax, ras, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 94930.81

Authors

Taylor, J.S.,Terry, K.L.,Beese, L.S. (deposition date: 2002-04-08, release date: 2002-06-19, Last modification date: 2023-08-16)

• Primary citation: Bell, I.M.,Gallicchio, S.N.,Abrams, M.,Beese, L.S.,Beshore, D.C.,Bhimnathwala, H.,Bogusky, M.J.,Buser, C.A.,Culberson, J.C.,Davide, J.,Ellis-Hutchings, M.,Fernandes, C.,Gibbs, J.B.,Graham, S.L.,Hamilton, K.A.,Hartman, G.D.,Heimbrook, D.C.,Homnick, C.F.,Huber, H.E.,Huff, J.R.,Kassahun, K.,Koblan, K.S.,Kohl, N.E.,Lobell, R.B.,Lynch Jr., J.J.,Robinson, R.,Rodrigues, A.D.,Taylor, J.S.,Walsh, E.S.,Williams, T.M.,Zartman, C.B.; 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.; J.Med.Chem., 45:2388-2409, 2002; PubMed: 12036349; DOI: 10.1021/jm010531d

Experimental method

X-RAY DIFFRACTION (2 Å)