1LD8
Co-crystal structure of Human Farnesyltransferase with farnesyldiphosphate and inhibitor compound 49
Summary for 1LD8
Entry DOI | 10.2210/pdb1ld8/pdb |
Related | 1JCQ 1LD7 |
Related PRD ID | PRD_900003 |
Descriptor | protein farnesyltransferase alpha subunit, protein farnesyltransferase beta subunit, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | alpha-alpha barrel, inhibitor, ftase, pftase, fpp, caax, ras, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 95032.86 |
Authors | Taylor, J.S.,Terry, K.L.,Beese, L.S. (deposition date: 2002-04-08, release date: 2002-06-19, Last modification date: 2023-08-16) |
Primary citation | Bell, I.M.,Gallicchio, S.N.,Abrams, M.,Beese, L.S.,Beshore, D.C.,Bhimnathwala, H.,Bogusky, M.J.,Buser, C.A.,Culberson, J.C.,Davide, J.,Ellis-Hutchings, M.,Fernandes, C.,Gibbs, J.B.,Graham, S.L.,Hamilton, K.A.,Hartman, G.D.,Heimbrook, D.C.,Homnick, C.F.,Huber, H.E.,Huff, J.R.,Kassahun, K.,Koblan, K.S.,Kohl, N.E.,Lobell, R.B.,Lynch Jr., J.J.,Robinson, R.,Rodrigues, A.D.,Taylor, J.S.,Walsh, E.S.,Williams, T.M.,Zartman, C.B. 3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency. J.Med.Chem., 45:2388-2409, 2002 Cited by PubMed: 12036349DOI: 10.1021/jm010531d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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