1S64

Rat protein geranylgeranyltransferase type-I complexed with L-778,123 and a sulfate anion

1S64 の概要

• エントリーDOI: 10.2210/pdb1s64/pdb
• 関連するPDBエントリー: 1JCQ 1LD7 1N4P 1N4Q 1O5M 1S63
• 分子名称: Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Geranylgeranyl transferase type I beta subunit, ZINC ION, ... (8 entities in total)
• 機能のキーワード: l-778, 123, protein geranylgeranyltransferase type-i, protein prenylation, lipid modification, drug, transferase
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 524280.54

構造登録者

Reid, T.S.,Long, S.B.,Beese, L.S. (登録日: 2004-01-22, 公開日: 2004-07-27, 最終更新日: 2023-08-23)

• 主引用文献: Reid, T.S.,Long, S.B.,Beese, L.S.; Crystallographic Analysis Reveals that Anticancer Clinical Candidate L-778,123 Inhibits Protein Farnesyltransferase and Geranylgeranyltransferase-I by Different Binding Modes.; Biochemistry, 43:9000-9008, 2004; PubMed: 15248757; DOI: 10.1021/bi049280b

実験手法

X-RAY DIFFRACTION (2.55 Å)