1S63

Human protein farnesyltransferase complexed with L-778,123 and FPP

1S63 の概要

• エントリーDOI: 10.2210/pdb1s63/pdb
• 関連するPDBエントリー: 1D8D 1FT1 1LD7 1LD8 1N4Q 1O5M 1S64
• 関連するBIRD辞書のPRD_ID: PRD_900003
• 分子名称: Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: farnesyltransferase, ftase, geranylgeranyltransferase, cancer, caax, fti, inhibitor, ras, lipid modification, protein prenylation, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 94883.16

構造登録者

Long, S.B.,Casey, P.J.,Beese, L.S. (登録日: 2004-01-22, 公開日: 2004-07-27, 最終更新日: 2023-08-23)

• 主引用文献: Reid, T.S.,Long, S.B.,Beese, L.S.; Crystallographic Analysis Reveals that Anticancer Clinical Candidate L-778,123 Inhibits Protein Farnesyltransferase and Geranylgeranyltransferase-I by Different Binding Modes.; Biochemistry, 43:9000-9008, 2004; PubMed: 15248757; DOI: 10.1021/bi049280b

実験手法

X-RAY DIFFRACTION (1.9 Å)