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1P17

Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, K68R mutant, complexed with the product IMP

Summary for 1P17
Entry DOI10.2210/pdb1p17/pdb
Related1p18 1p19 1tc1 1tc2
Descriptorhypoxanthine phosphoribosyltransferase, INOSINIC ACID (3 entities in total)
Functional Keywordstransferase, glycosyltransferase, phosphoribosyltransferase, nucleotide metabolism, purine salvage, product complex
Biological sourceTrypanosoma cruzi
Total number of polymer chains4
Total formula weight103886.50
Authors
Medrano, F.J.,Eakin, A.E.,Craig III, S.P. (deposition date: 2003-04-11, release date: 2004-05-18, Last modification date: 2024-02-14)
Primary citationCanyuk, B.,Medrano, F.J.,Wenck, M.A.,Focia, P.J.,Eakin, A.E.,Craig III, S.P.
Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase.
J.Mol.Biol., 335:905-921, 2004
Cited by
PubMed: 14698288
DOI: 10.1016/j.jmb.2003.11.012
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

217705

PDB entries from 2024-03-27

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