1P17

Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, K68R mutant, complexed with the product IMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	hypoxanthine phosphoribosyltransferase	polymer	221	25623.4	4	UniProt (Q27796) Pfam (PF00156) UniProt (by SIFTS) (Q4DRC4)	Trypanosoma cruzi
2	E, F, G, H (A, B, C, D)	INOSINIC ACID	non-polymer		348.2	4	Chemie (IMP)
3	I, J, K, L (A, B, C, D)	water	water		18.0	360	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 221 (UniProt: Q27796)

PDB	External Database	Details
Lys 23	Met 23	SEE REMARK 999
Arg 52	Lys 52	engineered mutation
Cys 66	Ser 66	SEE REMARK 999
Leu 86	Val 86	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	102493.7
Non-Polymers*	Number of molecules	4
	Total formula weight	1392.8
All*	Total formula weight	103886.5

*Water molecules are not included.