1P17
Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, K68R mutant, complexed with the product IMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | hypoxanthine phosphoribosyltransferase | polymer | 221 | 25623.4 | 4 | UniProt (Q27796) Pfam (PF00156) UniProt (by SIFTS) (Q4DRC4) | Trypanosoma cruzi | |
| 2 | E, F, G, H (A, B, C, D) | INOSINIC ACID | non-polymer | 348.2 | 4 | Chemie (IMP) PubChem (177678963) PubChem (135464200) PubChem (135533971) PubChem (138454308) PubChem (135398640) PubChem (135402036) PubChem (135449337) PubChem (135486133) PubChem (135530792) PubChem (135567013) PubChem (135705234) PubChem (135854804) PubChem (135889742) PubChem (136026456) PubChem (136073920) PubChem (136217866) PubChem (136259539) PubChem (136716177) PubChem (136766861) PubChem (136811071) PubChem (137162990) PubChem (137168789) PubChem (137257909) PubChem (162510533) PubChem (174152734) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 360 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 221 (UniProt: Q27796)
| PDB | External Database | Details |
|---|---|---|
| Lys 23 | Met 23 | SEE REMARK 999 |
| Arg 52 | Lys 52 | engineered mutation |
| Cys 66 | Ser 66 | SEE REMARK 999 |
| Leu 86 | Val 86 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 102493.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1392.8 | |
| All* | Total formula weight | 103886.5 |
