1P17
Hypoxanthine Phosphoribosyltransferase from Trypanosoma cruzi, K68R mutant, complexed with the product IMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0032264 | biological_process | IMP salvage |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0032264 | biological_process | IMP salvage |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0032264 | biological_process | IMP salvage |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0032264 | biological_process | IMP salvage |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE IMP A 3000 |
| Chain | Residue |
| A | GLU111 |
| A | LYS143 |
| A | PHE164 |
| A | VAL165 |
| A | ASP171 |
| A | ASP112 |
| A | ILE113 |
| A | VAL114 |
| A | ASP115 |
| A | THR116 |
| A | ALA117 |
| A | LEU118 |
| A | THR119 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE IMP B 3001 |
| Chain | Residue |
| B | GLU111 |
| B | ASP112 |
| B | ILE113 |
| B | ASP115 |
| B | THR116 |
| B | ALA117 |
| B | THR119 |
| B | LYS143 |
| B | ALA163 |
| B | PHE164 |
| B | VAL165 |
| B | ASP171 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE IMP C 3002 |
| Chain | Residue |
| C | ASP112 |
| C | ILE113 |
| C | ASP115 |
| C | THR116 |
| C | ALA117 |
| C | THR119 |
| C | LYS143 |
| C | ALA163 |
| C | PHE164 |
| C | VAL165 |
| C | ASP171 |
| C | HOH3003 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE IMP D 3003 |
| Chain | Residue |
| D | GLU111 |
| D | ASP112 |
| D | ILE113 |
| D | ASP115 |
| D | THR116 |
| D | ALA117 |
| D | LEU118 |
| D | THR119 |
| D | LYS143 |
| D | ALA163 |
| D | VAL165 |
| D | ASP171 |
| D | HOH3007 |
| D | HOH3008 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIVDTAlT |
| Chain | Residue | Details |
| A | VAL107-THR119 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| A | GLU111 | |
| A | LYS143 | |
| A | ASP112 | |
| A | ASP115 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| B | GLU111 | |
| B | LYS143 | |
| B | ASP112 | |
| B | ASP115 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| C | GLU111 | |
| C | LYS143 | |
| C | ASP112 | |
| C | ASP115 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| D | GLU111 | |
| D | LYS143 | |
| D | ASP112 | |
| D | ASP115 |
| site_id | CSA5 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| A | GLU111 | |
| A | LYS143 | |
| A | ASP112 | |
| A | ARG147 | |
| A | ASP115 |
| site_id | CSA6 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| B | GLU111 | |
| B | LYS143 | |
| B | ASP112 | |
| B | ARG147 | |
| B | ASP115 |
| site_id | CSA7 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| C | GLU111 | |
| C | LYS143 | |
| C | ASP112 | |
| C | ARG147 | |
| C | ASP115 |
| site_id | CSA8 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a95 |
| Chain | Residue | Details |
| D | GLU111 | |
| D | LYS143 | |
| D | ASP112 | |
| D | ARG147 | |
| D | ASP115 |
