1M78

CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH) AND 5-CHLORYL-2,4,6-QUINAZOLINETRIAMINE (GW1225)

1M78 の概要

• エントリーDOI: 10.2210/pdb1m78/pdb
• 関連するPDBエントリー: 1AI9 1AOE 1IA1 1IA2 1IA3 1IA4 1M79 1M7A
• 分子名称: DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-CHLORYL-2,4,6-QUINAZOLINETRIAMINE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, antifungal target, reductase
• 由来する生物種: Candida albicans
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46299.17

構造登録者

Whitlow, M.,Howard, A.J.,Kuyper, L.F. (登録日: 2002-07-19, 公開日: 2003-03-04, 最終更新日: 2023-08-23)

• 主引用文献: Whitlow, M.,Howard, A.J.,Stewart, D.,Hardman, K.D.,Kuyper, L.F.,Baccanari, D.P.,Fling, M.E.,Tansik, R.L.; X-Ray Crystallographic Studies of Candida Albicans Dihydrofolate Reductase. High Resolution Structures of the Holoenzyme and an Inhibited Ternary Complex.; J.Biol.Chem., 272:30289-30298, 1997; PubMed: 9374515; DOI: 10.1074/jbc.272.48.30289

実験手法

X-RAY DIFFRACTION (1.71 Å)