1IA2
Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE (GW578)
Summary for 1IA2
Entry DOI | 10.2210/pdb1ia2/pdb |
Related | 1AI9 1AOE 1IA1 1IA3 1IA4 |
Descriptor | DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE, ... (5 entities in total) |
Functional Keywords | oxidoreductase, antifungal target, reductase |
Biological source | Candida albicans |
Total number of polymer chains | 2 |
Total formula weight | 46835.10 |
Authors | Whitlow, M.,Howard, A.J.,Kuyper, L.F. (deposition date: 2001-03-22, release date: 2001-04-11, Last modification date: 2023-08-09) |
Primary citation | Whitlow, M.,Howard, A.J.,Stewart, D.,Hardman, K.D.,Chan, J.H.,Baccanari, D.P.,Tansik, R.L.,Hong, J.S.,Kuyper, L.F. X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH is Displaced by an inhibitor J.Med.Chem., 44:2928-2932, 2001 Cited by PubMed: 11520201DOI: 10.1021/jm0101444 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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