1IA4

Candida albicans dihydrofolate reductase complex in which the dihydronicotinamide moiety of dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) is displaced by 5-{[4-(4-MORPHOLINYL)PHENYL]SULFANYL}-2,4-QUINAZOLINEDIAMIN (GW2021)

Summary for 1IA4

Entry DOI	10.2210/pdb1ia4/pdb
Related	1AI9 1AOE 1IA1 1IA2 1IA3
Descriptor	DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(4-MORPHOLIN-4-YL-PHENYLSULFANYL)-2,4-QUINAZOLINEDIAMINE, ... (5 entities in total)
Functional Keywords	oxidoreductase, antifungal target, reductase, dihydronicotinamide displaced
Biological source	Candida albicans
Total number of polymer chains	2
Total formula weight	46977.25
Authors	Whitlow, M.,Howard, A.J.,Kuyper, L.F. (deposition date: 2001-03-22, release date: 2001-04-11, Last modification date: 2023-08-09)
Primary citation	Whitlow, M.,Howard, A.J.,Stewart, D.,Hardman, K.D.,Chan, J.H.,Baccanari, D.P.,Tansik, R.L.,Hong, J.S.,Kuyper, L.F. X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH is Displaced by an inhibitor J.Med.Chem., 44:2928-2932, 2001 Cited by PubMed: 11520201 DOI: 10.1021/jm0101444 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation