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1IA4

Candida albicans dihydrofolate reductase complex in which the dihydronicotinamide moiety of dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) is displaced by 5-{[4-(4-MORPHOLINYL)PHENYL]SULFANYL}-2,4-QUINAZOLINEDIAMIN (GW2021)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
DIHYDROFOLATE REDUCTASEpolymer19222194.52UniProt (P22906)
Pfam (PF00186)
Candida albicans
2C, F
(A, B)
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer745.42Chemie (NDP)
3D, G
(A, B)
5-(4-MORPHOLIN-4-YL-PHENYLSULFANYL)-2,4-QUINAZOLINEDIAMINEnon-polymer353.42Chemie (TQ6)
4E, H
(A, B)
2-(N-MORPHOLINO)-ETHANESULFONIC ACIDnon-polymer195.22Chemie (MES)
5I, J
(A, B)
waterwater18.0319Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight44389.1
Non-Polymers*Number of molecules6
Total formula weight2588.2
All*Total formula weight46977.3
*Water molecules are not included.

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PDB entries from 2025-07-02

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