1IA4
Candida albicans dihydrofolate reductase complex in which the dihydronicotinamide moiety of dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) is displaced by 5-{[4-(4-MORPHOLINYL)PHENYL]SULFANYL}-2,4-QUINAZOLINEDIAMIN (GW2021)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B (A, B) | DIHYDROFOLATE REDUCTASE | polymer | 192 | 22194.5 | 2 | UniProt (P22906) Pfam (PF00186) | Candida albicans | |
2 | C, F (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
3 | D, G (A, B) | 5-(4-MORPHOLIN-4-YL-PHENYLSULFANYL)-2,4-QUINAZOLINEDIAMINE | non-polymer | 353.4 | 2 | Chemie (TQ6) | |||
4 | E, H (A, B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 2 | Chemie (MES) | |||
5 | I, J (A, B) | water | water | 18.0 | 319 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 44389.1 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 2588.2 | |
All* | Total formula weight | 46977.3 |