1M79

Candida albicans Dihydrofolate Reductase Complexed with Dihydro-Nicotinamide-Adenine-Dinucleotide Phosphate (NADPH) and 5-(4-methoxyphenoxy)-2,4-quinazolinediamine (GW1466)

Summary for 1M79

Entry DOI	10.2210/pdb1m79/pdb
Related	1AI1 1AI2 1AI3 1AI4 1AI9 1AOE 1M78 1m7a
Descriptor	dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(4-METHOXYPHENOXY)-2,4-QUINAZOLINEDIAMINE, ... (5 entities in total)
Functional Keywords	oxidoreductase, antifungal target, reductase
Biological source	Candida albicans
Total number of polymer chains	2
Total formula weight	46834.96
Authors	Whitlow, M.,Howard, A.J.,Kuyper, L.F. (deposition date: 2002-07-19, release date: 2003-03-04, Last modification date: 2024-02-14)
Primary citation	Whitlow, M.,Howard, A.J.,Stewart, D.,Hardman, K.D.,Kuyper, L.F.,Baccanari, D.P.,Fling, M.E.,Tansik, R.L. X-Ray Crystallographic Studies of Candida Albicans Dihydrofolate Reductase. High Resolution Structures of the Holoenzyme and an Inhibited Ternary Complex J.Biol.Chem., 272:30289-30298, 1997 Cited by PubMed: 9374515 DOI: 10.1074/jbc.272.48.30289 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation