1M78
CANDIDA ALBICANS DIHYDROFOLATE REDUCTASE COMPLEXED WITH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (NADPH) AND 5-CHLORYL-2,4,6-QUINAZOLINETRIAMINE (GW1225)
Summary for 1M78
| Entry DOI | 10.2210/pdb1m78/pdb |
| Related | 1AI9 1AOE 1IA1 1IA2 1IA3 1IA4 1M79 1M7A |
| Descriptor | DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-CHLORYL-2,4,6-QUINAZOLINETRIAMINE, ... (4 entities in total) |
| Functional Keywords | oxidoreductase, antifungal target, reductase |
| Biological source | Candida albicans |
| Total number of polymer chains | 2 |
| Total formula weight | 46299.17 |
| Authors | Whitlow, M.,Howard, A.J.,Kuyper, L.F. (deposition date: 2002-07-19, release date: 2003-03-04, Last modification date: 2023-08-23) |
| Primary citation | Whitlow, M.,Howard, A.J.,Stewart, D.,Hardman, K.D.,Kuyper, L.F.,Baccanari, D.P.,Fling, M.E.,Tansik, R.L. X-Ray Crystallographic Studies of Candida Albicans Dihydrofolate Reductase. High Resolution Structures of the Holoenzyme and an Inhibited Ternary Complex. J.Biol.Chem., 272:30289-30298, 1997 Cited by PubMed: 9374515DOI: 10.1074/jbc.272.48.30289 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.71 Å) |
Structure validation
Download full validation report
