1HY7
A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3
Summary for 1HY7
Entry DOI | 10.2210/pdb1hy7/pdb |
Related | 1CQR 1D5J 1D7X 1D8F 1D8M 1G49 |
Descriptor | STROMELYSIN-1, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | mixed alpha beta structure, zinc protease, inhibited, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix : P08254 |
Total number of polymer chains | 2 |
Total formula weight | 39738.61 |
Authors | Natchus, M.G.,Bookland, R.G.,Laufersweiler, M.J.,Pikul, S.,Almstead, N.G.,De, B.,Janusz, M.J.,Hsieh, L.C.,Gu, F.,Pokross, M.E.,Patel, V.S.,Garver, S.M.,Peng, S.X.,Branch, T.M.,King, S.L.,Baker, T.R.,Foltz, D.J.,Mieling, G.E. (deposition date: 2001-01-18, release date: 2002-01-18, Last modification date: 2024-02-07) |
Primary citation | Natchus, M.G.,Bookland, R.G.,Laufersweiler, M.J.,Pikul, S.,Almstead, N.G.,De, B.,Janusz, M.J.,Hsieh, L.C.,Gu, F.,Pokross, M.E.,Patel, V.S.,Garver, S.M.,Peng, S.X.,Branch, T.M.,King, S.L.,Baker, T.R.,Foltz, D.J.,Mieling, G.E. Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines. J.Med.Chem., 44:1060-1071, 2001 Cited by PubMed: 11297453DOI: 10.1021/jm000477l PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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