Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | HIS201 |
| A | HIS205 |
| A | HIS211 |
| A | HOH379 |
| B | THR755 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| Chain | Residue |
| A | HIS151 |
| A | ASP153 |
| A | HIS166 |
| A | HIS179 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 303 |
| Chain | Residue |
| A | ASP158 |
| A | GLY159 |
| A | GLY161 |
| A | VAL163 |
| A | ASP181 |
| A | GLU184 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 304 |
| Chain | Residue |
| A | ASP107 |
| A | ASP182 |
| A | GLU184 |
| A | HOH326 |
| A | HOH341 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 305 |
| Chain | Residue |
| A | ASP141 |
| A | GLY173 |
| A | ASN175 |
| A | ASP177 |
| A | HOH306 |
| A | HOH307 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 801 |
| Chain | Residue |
| B | HIS701 |
| B | HIS705 |
| B | HIS711 |
| B | MBS901 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 802 |
| Chain | Residue |
| B | HIS651 |
| B | ASP653 |
| B | HIS666 |
| B | HIS679 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 803 |
| Chain | Residue |
| B | ASP658 |
| B | GLY659 |
| B | GLY661 |
| B | VAL663 |
| B | ASP681 |
| B | GLU684 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 804 |
| Chain | Residue |
| B | HOH20 |
| B | HOH52 |
| B | ASP607 |
| B | ASP682 |
| B | GLU684 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 805 |
| Chain | Residue |
| B | HOH12 |
| B | HOH64 |
| B | ASP641 |
| B | GLY673 |
| B | ASN675 |
| B | ASP677 |
| site_id | BC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE MBS B 901 |
| Chain | Residue |
| B | HOH76 |
| B | HOH109 |
| B | HOH221 |
| B | VAL663 |
| B | LEU664 |
| B | ALA665 |
| B | HIS666 |
| B | LEU697 |
| B | HIS701 |
| B | GLU702 |
| B | HIS705 |
| B | HIS711 |
| B | LEU718 |
| B | TYR720 |
| B | PRO721 |
| B | LEU722 |
| B | ZN801 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEIGHSL |
| Chain | Residue | Details |
| A | VAL198-LEU207 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | GLU202 | |
| B | GLU702 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP107 | |
| A | GLY173 | |
| A | ASN175 | |
| A | ASP177 | |
| A | HIS179 | |
| A | ASP181 | |
| A | ASP182 | |
| A | GLU184 | |
| B | ASP607 | |
| B | ASP641 | |
| B | HIS651 | |
| A | ASP141 | |
| B | ASP653 | |
| B | ASP658 | |
| B | GLY659 | |
| B | GLY661 | |
| B | VAL663 | |
| B | HIS666 | |
| B | GLY673 | |
| B | ASN675 | |
| B | ASP677 | |
| B | HIS679 | |
| A | HIS151 | |
| B | ASP681 | |
| B | ASP682 | |
| B | GLU684 | |
| A | ASP153 | |
| A | ASP158 | |
| A | GLY159 | |
| A | GLY161 | |
| A | VAL163 | |
| A | HIS166 | |
| Chain | Residue | Details |
| A | HIS201 | |
| A | HIS205 | |
| A | HIS211 | |
| B | HIS701 | |
| B | HIS705 | |
| B | HIS711 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | MET219 | |
| A | GLU202 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| B | GLU702 | |
| B | MET719 | |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | GLU202 | |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| B | GLU702 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 591 |
| Chain | Residue | Details |
| A | HIS201 | metal ligand |
| A | GLU202 | proton acceptor, proton donor |
| A | HIS205 | metal ligand |
| A | HIS211 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 591 |
| Chain | Residue | Details |
| B | HIS701 | metal ligand |
| B | GLU702 | proton acceptor, proton donor |
| B | HIS705 | metal ligand |
| B | HIS711 | metal ligand |
