1G49
A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3
Summary for 1G49
Entry DOI | 10.2210/pdb1g49/pdb |
Related | 1CQR 1D5J 1D7X 1D8F 1D8M 1G05 |
Descriptor | MATRIX METALLOPROTEINASE 3, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | mixed alpha beta structure, zinc protease, inhibited, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix : P08254 |
Total number of polymer chains | 2 |
Total formula weight | 39770.68 |
Authors | Natchus, M.G.,Bookland, R.G.,De, B.,Almstead, N.G.,Pikul, S. (deposition date: 2000-10-26, release date: 2001-10-24, Last modification date: 2024-02-07) |
Primary citation | Natchus, M.G.,Bookland, R.G.,De, B.,Almstead, N.G.,Pikul, S. Development of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines. J.Med.Chem., 43:4948-4963, 2000 Cited by PubMed: 11150165DOI: 10.1021/jm000246e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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