1H25

CDK2/Cyclin A in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein

Summary for 1H25

Related1AD6 1GH6 1GUX 1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1QMZ
DescriptorCELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-ASSOCIATED PROTEIN, ... (4 entities in total)
Functional Keywordstransferase, cell cycle, protein kinase, cyclin, cdk2, recruitment, peptide specificity
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus P20248 P06400
Total number of polymer chains5
Total molecular weight129785.34
Authors
Tews, I.,Cheng, K.Y.,Lowe, E.D.,Noble, M.E.M.,Brown, N.R.,Gul, S.,Gamblin, S.,Johnson, L.N. (deposition date: 2002-07-31, release date: 2003-02-01, Last modification date: 2011-07-13)
Primary citation
Lowe, E.D.,Tews, I.,Cheng, K.Y.,Brown, N.R.,Gul, S.,Noble, M.E.M.,Gamblin, S.,Johnson, L.N.
Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41:15625-, 2002
PubMed: 12501191 (PDB entries with the same primary citation)
DOI: 10.1021/BI0268910
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.307282.7%6.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report