1E2G

Human thymidylate kinase complexed with ADP, TDP and a magnesium-ion

1E2G の概要

• エントリーDOI: 10.2210/pdb1e2g/pdb
• 関連するPDBエントリー: 1E2D 1E2E 1E2F 1E2Q 1E98 1E99 1E9A 1E9B 1E9C 1E9D 1E9E 1E9F 1NMX 1NMY 1NMZ 1NN0 1NN1 1NN3 1NN5 2XX3
• 分子名称: THYMIDYLATE KINASE, THYMIDINE-5'-PHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• 機能のキーワード: transferase, p-loop
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25252.74

構造登録者

Ostermann, N.,Schlichting, I.,Brundiers, R.,Konrad, M.,Reinstein, J.,Veit, T.,Goody, R.S.,Lavie, A. (登録日: 2000-05-22, 公開日: 2001-05-17, 最終更新日: 2024-05-08)

主引用文献

Ostermann, N.,Schlichting, I.,Brundiers, R.,Konrad, M.,Reinstein, J.,Veit, T.,Goody, R.S.,Lavie, A.
Insights Into the Phosphoryltransfer Mechanism of Human Thymidylate Kinase Gained from Crystal Structures of Enzyme Complexes Along the Reaction Coordinate
Structure, 8:629-, 2000

PubMed Abstract: Thymidylate kinase (TMPK) is a nucleoside monophosphate kinase that catalyzes the reversible phosphoryltransfer between ATP and TMP to yield ADP and TDP. In addition to its vital role in supplying precursors for DNA synthesis, human TMPK has an important medical role participating in the activation of a number of anti-HIV prodrugs.

PubMed: 10873853
DOI: 10.1016/S0969-2126(00)00149-0

実験手法

X-RAY DIFFRACTION (1.7 Å)