1E2G

Human thymidylate kinase complexed with ADP, TDP and a magnesium-ion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0004798	molecular_function	dTMP kinase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006227	biological_process	dUDP biosynthetic process
A	0006233	biological_process	dTDP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0046105	biological_process	thymidine biosynthetic process
A	0071363	biological_process	cellular response to growth factor stimulus

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE TMP A 301

Chain	Residue
A	ASP15
A	HOH2124
A	HOH2128
A	HOH2249
A	HOH2250
A	HOH2251
A	HOH2252
A	HOH2269
A	PHE42
A	LEU57
A	PHE72
A	ARG76
A	ARG97
A	GLY102
A	PHE105
A	TYR151

---

site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE ADP A 302

Chain	Residue
A	ARG16
A	ALA17
A	GLY18
A	LYS19
A	SER20
A	THR21
A	ARG143
A	LYS182
A	SER183
A	ILE184
A	ARG192
A	MG401
A	HOH2230
A	HOH2252
A	HOH2254
A	HOH2255
A	HOH2256
A	HOH2257
A	HOH2258
A	HOH2259
A	HOH2260
A	HOH2261

---

site_id	AC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE TYD A 304

Chain	Residue
A	ASP15
A	PHE42
A	ARG45
A	LEU57
A	PHE72
A	ARG76
A	ARG97
A	GLY102
A	PHE105
A	TYR151
A	GLU152
A	HOH2068
A	HOH2249
A	HOH2250
A	HOH2251
A	HOH2252
A	HOH2262
A	HOH2263
A	HOH2264
A	HOH2265
A	HOH2266
A	HOH2267
A	HOH2268
A	HOH2269

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 401

Chain	Residue
A	SER20
A	ADP302
A	HOH2124
A	HOH2252
A	HOH2259
A	HOH2267

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 402

Chain	Residue
A	HOH2061
A	HOH2061
A	HOH2142
A	HOH2142
A	HOH2144
A	HOH2144

---

Functional Information from PROSITE/UniProt

site_id	PS01331
Number of Residues	13
Details	THYMIDYLATE_KINASE Thymidylate kinase signature. VVDRYafSGvAFT

Chain	Residue	Details
A	VAL94-THR106

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:12614151, ECO:0007744|PDB:1NMX, ECO:0007744|PDB:1NMY, ECO:0007744|PDB:1NN0, ECO:0007744|PDB:1NN3

Chain	Residue	Details
A	ARG16

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:12614151, ECO:0007744|PDB:1NMY, ECO:0007744|PDB:1NMZ, ECO:0007744|PDB:1NN1

Chain	Residue	Details
A	ARG97

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0007744|PDB:1NMX, ECO:0007744|PDB:1NMY, ECO:0007744|PDB:1NN0, ECO:0007744|PDB:1NN3

Chain	Residue	Details
A	LYS182

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0007744|PDB:1NMY, ECO:0007744|PDB:1NMZ, ECO:0007744|PDB:1NN1, ECO:0007744|PDB:1NN5

Chain	Residue	Details
A	ARG192

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	ALA2

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS169

---