1DTQ

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-1 (PETT131A94)

Summary for 1DTQ

• Entry DOI: 10.2210/pdb1dtq/pdb
• Related: 1DTT 1c0t 1c0u 1c1b 1c1c 1klm 1rev 1rt1 1rt2 1rt3 1rt4 1rt5 1rt6 1rt7 1rth 1rti 1rtj 1rtv 1vru
• Descriptor: HIV-1 RT A-CHAIN, HIV-1 RT B-CHAIN, N-[[3-FLUORO-4-ETHOXY-PYRID-2-YL]ETHYL]-N'-[5-NITRILOMETHYL-PYRIDYL]-THIOUREA, ... (4 entities in total)
• Functional Keywords: hiv-1 reverse transcriptase aids, non-nucleoside inhibitor, drug design, hydrolase-transferase complex, hydrolase/transferase
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Matrix protein p17: Virion . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
• Total number of polymer chains: 2
• Total formula weight: 116339.39

Authors

Ren, J.,Diprose, J.,Warren, J.,Esnouf, R.M.,Bird, L.E.,Ikemizu, S.,Slater, M.,Milton, J.,Balzarini, J.,Stuart, D.I.,Stammers, D.K. (deposition date: 2000-01-13, release date: 2000-03-20, Last modification date: 2014-11-12)

• Primary citation: Ren, J.,Diprose, J.,Warren, J.,Esnouf, R.M.,Bird, L.E.,Ikemizu, S.,Slater, M.,Milton, J.,Balzarini, J.,Stuart, D.I.,Stammers, D.K.; Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.; J.Biol.Chem., 275:5633-5639, 2000; PubMed: 10681546; DOI: 10.1074/jbc.275.8.5633

Experimental method

X-RAY DIFFRACTION (2.8 Å)