1N0T
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with the antagonist (S)-ATPO at 2.1 A resolution.
Summary for 1N0T
Entry DOI | 10.2210/pdb1n0t/pdb |
Related | 1FTJ 1FTK 1FTL 1FTM 1FTO 1FWO 1GR2 1LB8 1LB9 1LBB 1LBC 1M5B 1M5C 1M5D 1M5E 1M5F 1MM6 1MM7 |
Descriptor | Glutamate receptor 2, (S)-2-AMINO-3-(5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL)PROPIONIC ACID, SULFATE ION, ... (5 entities in total) |
Functional Keywords | ionotropic glutamate receptor glur2, ligand-binding core, antagonist complex, membrane protein |
Biological source | Rattus norvegicus (Norway rat) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P19491 |
Total number of polymer chains | 4 |
Total formula weight | 118619.03 |
Authors | Hogner, A.,Greenwood, J.R.,Liljefors, T.,Lunn, M.-L.,Egebjerg, J.,Larsen, I.K.,Gouaux, E.,Kastrup, J.S. (deposition date: 2002-10-15, release date: 2003-03-04, Last modification date: 2017-08-16) |
Primary citation | Hogner, A.,Greenwood, J.R.,Liljefors, T.,Lunn, M.L.,Egebjerg, J.,Larsen, I.K.,Gouaux, E.,Kastrup, J.S. Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX. J.Med.Chem., 46:214-221, 2003 Cited by PubMed: 12519060DOI: 10.1021/jm020989v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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