1HY7

A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3

Summary for 1HY7

• Entry DOI: 10.2210/pdb1hy7/pdb
• Related: 1CQR 1D5J 1D7X 1D8F 1D8M 1G49
• Descriptor: STROMELYSIN-1, ZINC ION, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: mixed alpha beta structure, zinc protease, inhibited, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space, extracellular matrix : P08254
• Total number of polymer chains: 2
• Total formula weight: 39738.61

Authors

Natchus, M.G.,Bookland, R.G.,Laufersweiler, M.J.,Pikul, S.,Almstead, N.G.,De, B.,Janusz, M.J.,Hsieh, L.C.,Gu, F.,Pokross, M.E.,Patel, V.S.,Garver, S.M.,Peng, S.X.,Branch, T.M.,King, S.L.,Baker, T.R.,Foltz, D.J.,Mieling, G.E. (deposition date: 2001-01-18, release date: 2002-01-18, Last modification date: 2024-02-07)

• Primary citation: Natchus, M.G.,Bookland, R.G.,Laufersweiler, M.J.,Pikul, S.,Almstead, N.G.,De, B.,Janusz, M.J.,Hsieh, L.C.,Gu, F.,Pokross, M.E.,Patel, V.S.,Garver, S.M.,Peng, S.X.,Branch, T.M.,King, S.L.,Baker, T.R.,Foltz, D.J.,Mieling, G.E.; Development of new carboxylic acid-based MMP inhibitors derived from functionalized propargylglycines.; J.Med.Chem., 44:1060-1071, 2001; PubMed: 11297453; DOI: 10.1021/jm000477l

Experimental method

X-RAY DIFFRACTION (1.5 Å)