1G49

A CARBOXYLIC ACID BASED INHIBITOR IN COMPLEX WITH MMP3

Summary for 1G49

Entry DOI	10.2210/pdb1g49/pdb
Related	1CQR 1D5J 1D7X 1D8F 1D8M 1G05
Descriptor	MATRIX METALLOPROTEINASE 3, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	mixed alpha beta structure, zinc protease, inhibited, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix : P08254
Total number of polymer chains	2
Total formula weight	39770.68
Authors	Natchus, M.G.,Bookland, R.G.,De, B.,Almstead, N.G.,Pikul, S. (deposition date: 2000-10-26, release date: 2001-10-24, Last modification date: 2024-02-07)
Primary citation	Natchus, M.G.,Bookland, R.G.,De, B.,Almstead, N.G.,Pikul, S. Development of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines. J.Med.Chem., 43:4948-4963, 2000 Cited by PubMed: 11150165 DOI: 10.1021/jm000246e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation