8U4T

Structure of tetrameric CXCR4 in complex with REGN7663 Fab

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (L, F, O, Y)	REGN7663 Fab light chain	polymer	219	24185.9	4		Homo sapiens (human)
2	B, E, H, K (H, G, P, Z)	REGN7663 Fab heavy chain	polymer	240	25799.9	4		Homo sapiens (human)
3	C, F, I, L (R, I, Q, AA)	C-X-C chemokine receptor type 4	polymer	632	71063.6	4	UniProt (P61073) Pfam (PF12109) Pfam (PF00001)	Homo sapiens (human)
4	AA, BA, CA, DA, FA... (Q, AA, R, I)	CHOLESTEROL	non-polymer		386.7	16	Chemie (CLR)
5	EA, P, U, Z (AA, R, I, Q)	(2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate	non-polymer		674.9	4	Chemie (D21)

Sequence modifications

R, I, Q, AA: 2 - 352 (UniProt: P61073)

PDB	External Database	Details
Met -17	-	initiating methionine
Lys -16	-	expression tag
Thr -15	-	expression tag
Ile -14	-	expression tag
Ile -13	-	expression tag
Ala -12	-	expression tag
Leu -11	-	expression tag
Ser -10	-	expression tag
Tyr -9	-	expression tag
Ile -8	-	expression tag
Phe -7	-	expression tag
Cys -6	-	expression tag
Leu -5	-	expression tag
Val -4	-	expression tag
Phe -3	-	expression tag
Ala -2	-	expression tag
Gly -1	-	expression tag
Ala 0	-	expression tag
Pro 1	-	expression tag
Ser 119	Asn 119	conflict

R, I, Q, AA: 353 - 614 (PDB: 8U4T)

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	484197.8
Non-Polymers*	Number of molecules	20
	Total formula weight	8886.2
All*	Total formula weight	493084.0

*Water molecules are not included.