8U4T
Structure of tetrameric CXCR4 in complex with REGN7663 Fab
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J (L, F, O, Y) | REGN7663 Fab light chain | polymer | 219 | 24185.9 | 4 | Homo sapiens (human) | ||
| 2 | B, E, H, K (H, G, P, Z) | REGN7663 Fab heavy chain | polymer | 240 | 25799.9 | 4 | Homo sapiens (human) | ||
| 3 | C, F, I, L (R, I, Q, AA) | C-X-C chemokine receptor type 4 | polymer | 632 | 71063.6 | 4 | UniProt (P61073) Pfam (PF12109) Pfam (PF00001) | Homo sapiens (human) | |
| 4 | AA, BA, CA, DA, FA... (Q, AA, R, I) | CHOLESTEROL | non-polymer | 386.7 | 16 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (45044259) PubChem (49853509) PubChem (50990013) PubChem (176980071) PubChem (18640088) PubChem (52934537) PubChem (1715243) PubChem (1715244) PubChem (23423981) PubChem (44654663) PubChem (46937002) PubChem (56621683) PubChem (59274407) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (5997) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (1551269) PubChem (90070115) PubChem (59450329) PubChem (59628412) PubChem (117965027) PubChem (6432564) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (132837164) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (304) PubChem (138967089) PubChem (139566851) PubChem (89951918) PubChem (90224410) PubChem (15939944) PubChem (91298236) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (638019) PubChem (101624109) PubChem (1549081) PubChem (1553803) PubChem (171828367) PubChem (173516975) PubChem (124225449) PubChem (124429284) PubChem (5283629) PubChem (5284644) PubChem (5315842) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (6419195) PubChem (6994560) PubChem (130459183) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (131992107) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (139568882) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 5 | EA, P, U, Z (AA, R, I, Q) | (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate | non-polymer | 674.9 | 4 | Chemie (D21) PubChem (656793) PubChem (3247007) PubChem (5282296) PubChem (101763346) PubChem (5771761) PubChem (124511017) PubChem (5283523) PubChem (13848341) |
Sequence modifications
R, I, Q, AA: 2 - 352 (UniProt: P61073)
R, I, Q, AA: 353 - 614 (PDB: 8U4T)
| PDB | External Database | Details |
|---|---|---|
| Met -17 | - | initiating methionine |
| Lys -16 | - | expression tag |
| Thr -15 | - | expression tag |
| Ile -14 | - | expression tag |
| Ile -13 | - | expression tag |
| Ala -12 | - | expression tag |
| Leu -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Tyr -9 | - | expression tag |
| Ile -8 | - | expression tag |
| Phe -7 | - | expression tag |
| Cys -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Val -4 | - | expression tag |
| Phe -3 | - | expression tag |
| Ala -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Ser 119 | Asn 119 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 484197.8 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 8886.2 | |
| All* | Total formula weight | 493084.0 |
