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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8U4T

Structure of tetrameric CXCR4 in complex with REGN7663 Fab

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AA0001618molecular_functionvirus receptor activity
AA0001666biological_processresponse to hypoxia
AA0002407biological_processdendritic cell chemotaxis
AA0003779molecular_functionactin binding
AA0004930molecular_functionG protein-coupled receptor activity
AA0005515molecular_functionprotein binding
AA0005737cellular_componentcytoplasm
AA0005764cellular_componentlysosome
AA0005769cellular_componentearly endosome
AA0005770cellular_componentlate endosome
AA0005886cellular_componentplasma membrane
AA0006091biological_processgeneration of precursor metabolites and energy
AA0006915biological_processapoptotic process
AA0006954biological_processinflammatory response
AA0006955biological_processimmune response
AA0007165biological_processsignal transduction
AA0007186biological_processG protein-coupled receptor signaling pathway
AA0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
AA0007204biological_processpositive regulation of cytosolic calcium ion concentration
AA0007420biological_processbrain development
AA0008218biological_processbioluminescence
AA0009615biological_processresponse to virus
AA0009897cellular_componentexternal side of plasma membrane
AA0009986cellular_componentcell surface
AA0015026molecular_functioncoreceptor activity
AA0016020cellular_componentmembrane
AA0016477biological_processcell migration
AA0016493molecular_functionC-C chemokine receptor activity
AA0016494molecular_functionC-X-C chemokine receptor activity
AA0019722biological_processcalcium-mediated signaling
AA0019955molecular_functioncytokine binding
AA0019957molecular_functionC-C chemokine binding
AA0022008biological_processneurogenesis
AA0030155biological_processregulation of cell adhesion
AA0030334biological_processregulation of cell migration
AA0030335biological_processpositive regulation of cell migration
AA0031252cellular_componentcell leading edge
AA0031410cellular_componentcytoplasmic vesicle
AA0031625molecular_functionubiquitin protein ligase binding
AA0032027molecular_functionmyosin light chain binding
AA0032991cellular_componentprotein-containing complex
AA0038147molecular_functionC-X-C motif chemokine 12 receptor activity
AA0038160biological_processCXCL12-activated CXCR4 signaling pathway
AA0043130molecular_functionubiquitin binding
AA0043217biological_processmyelin maintenance
AA0046718biological_processsymbiont entry into host cell
AA0048714biological_processpositive regulation of oligodendrocyte differentiation
AA0060326biological_processcell chemotaxis
AA0070062cellular_componentextracellular exosome
AA0070098biological_processchemokine-mediated signaling pathway
AA0070161cellular_componentanchoring junction
AA0071345biological_processcellular response to cytokine stimulus
AA0120162biological_processpositive regulation of cold-induced thermogenesis
AA1904018biological_processpositive regulation of vasculature development
AA2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
I0001618molecular_functionvirus receptor activity
I0001666biological_processresponse to hypoxia
I0002407biological_processdendritic cell chemotaxis
I0003779molecular_functionactin binding
I0004930molecular_functionG protein-coupled receptor activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005764cellular_componentlysosome
I0005769cellular_componentearly endosome
I0005770cellular_componentlate endosome
I0005886cellular_componentplasma membrane
I0006091biological_processgeneration of precursor metabolites and energy
I0006915biological_processapoptotic process
I0006954biological_processinflammatory response
I0006955biological_processimmune response
I0007165biological_processsignal transduction
I0007186biological_processG protein-coupled receptor signaling pathway
I0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
I0007204biological_processpositive regulation of cytosolic calcium ion concentration
I0007420biological_processbrain development
I0008218biological_processbioluminescence
I0009615biological_processresponse to virus
I0009897cellular_componentexternal side of plasma membrane
I0009986cellular_componentcell surface
I0015026molecular_functioncoreceptor activity
I0016020cellular_componentmembrane
I0016477biological_processcell migration
I0016493molecular_functionC-C chemokine receptor activity
I0016494molecular_functionC-X-C chemokine receptor activity
I0019722biological_processcalcium-mediated signaling
I0019955molecular_functioncytokine binding
I0019957molecular_functionC-C chemokine binding
I0022008biological_processneurogenesis
I0030155biological_processregulation of cell adhesion
I0030334biological_processregulation of cell migration
I0030335biological_processpositive regulation of cell migration
I0031252cellular_componentcell leading edge
I0031410cellular_componentcytoplasmic vesicle
I0031625molecular_functionubiquitin protein ligase binding
I0032027molecular_functionmyosin light chain binding
I0032991cellular_componentprotein-containing complex
I0038147molecular_functionC-X-C motif chemokine 12 receptor activity
I0038160biological_processCXCL12-activated CXCR4 signaling pathway
I0043130molecular_functionubiquitin binding
I0043217biological_processmyelin maintenance
I0046718biological_processsymbiont entry into host cell
I0048714biological_processpositive regulation of oligodendrocyte differentiation
I0060326biological_processcell chemotaxis
I0070062cellular_componentextracellular exosome
I0070098biological_processchemokine-mediated signaling pathway
I0070161cellular_componentanchoring junction
I0071345biological_processcellular response to cytokine stimulus
I0120162biological_processpositive regulation of cold-induced thermogenesis
I1904018biological_processpositive regulation of vasculature development
I2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
Q0001618molecular_functionvirus receptor activity
Q0001666biological_processresponse to hypoxia
Q0002407biological_processdendritic cell chemotaxis
Q0003779molecular_functionactin binding
Q0004930molecular_functionG protein-coupled receptor activity
Q0005515molecular_functionprotein binding
Q0005737cellular_componentcytoplasm
Q0005764cellular_componentlysosome
Q0005769cellular_componentearly endosome
Q0005770cellular_componentlate endosome
Q0005886cellular_componentplasma membrane
Q0006091biological_processgeneration of precursor metabolites and energy
Q0006915biological_processapoptotic process
Q0006954biological_processinflammatory response
Q0006955biological_processimmune response
Q0007165biological_processsignal transduction
Q0007186biological_processG protein-coupled receptor signaling pathway
Q0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Q0007204biological_processpositive regulation of cytosolic calcium ion concentration
Q0007420biological_processbrain development
Q0008218biological_processbioluminescence
Q0009615biological_processresponse to virus
Q0009897cellular_componentexternal side of plasma membrane
Q0009986cellular_componentcell surface
Q0015026molecular_functioncoreceptor activity
Q0016020cellular_componentmembrane
Q0016477biological_processcell migration
Q0016493molecular_functionC-C chemokine receptor activity
Q0016494molecular_functionC-X-C chemokine receptor activity
Q0019722biological_processcalcium-mediated signaling
Q0019955molecular_functioncytokine binding
Q0019957molecular_functionC-C chemokine binding
Q0022008biological_processneurogenesis
Q0030155biological_processregulation of cell adhesion
Q0030334biological_processregulation of cell migration
Q0030335biological_processpositive regulation of cell migration
Q0031252cellular_componentcell leading edge
Q0031410cellular_componentcytoplasmic vesicle
Q0031625molecular_functionubiquitin protein ligase binding
Q0032027molecular_functionmyosin light chain binding
Q0032991cellular_componentprotein-containing complex
Q0038147molecular_functionC-X-C motif chemokine 12 receptor activity
Q0038160biological_processCXCL12-activated CXCR4 signaling pathway
Q0043130molecular_functionubiquitin binding
Q0043217biological_processmyelin maintenance
Q0046718biological_processsymbiont entry into host cell
Q0048714biological_processpositive regulation of oligodendrocyte differentiation
Q0060326biological_processcell chemotaxis
Q0070062cellular_componentextracellular exosome
Q0070098biological_processchemokine-mediated signaling pathway
Q0070161cellular_componentanchoring junction
Q0071345biological_processcellular response to cytokine stimulus
Q0120162biological_processpositive regulation of cold-induced thermogenesis
Q1904018biological_processpositive regulation of vasculature development
Q2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
R0001618molecular_functionvirus receptor activity
R0001666biological_processresponse to hypoxia
R0002407biological_processdendritic cell chemotaxis
R0003779molecular_functionactin binding
R0004930molecular_functionG protein-coupled receptor activity
R0005515molecular_functionprotein binding
R0005737cellular_componentcytoplasm
R0005764cellular_componentlysosome
R0005769cellular_componentearly endosome
R0005770cellular_componentlate endosome
R0005886cellular_componentplasma membrane
R0006091biological_processgeneration of precursor metabolites and energy
R0006915biological_processapoptotic process
R0006954biological_processinflammatory response
R0006955biological_processimmune response
R0007165biological_processsignal transduction
R0007186biological_processG protein-coupled receptor signaling pathway
R0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0007420biological_processbrain development
R0008218biological_processbioluminescence
R0009615biological_processresponse to virus
R0009897cellular_componentexternal side of plasma membrane
R0009986cellular_componentcell surface
R0015026molecular_functioncoreceptor activity
R0016020cellular_componentmembrane
R0016477biological_processcell migration
R0016493molecular_functionC-C chemokine receptor activity
R0016494molecular_functionC-X-C chemokine receptor activity
R0019722biological_processcalcium-mediated signaling
R0019955molecular_functioncytokine binding
R0019957molecular_functionC-C chemokine binding
R0022008biological_processneurogenesis
R0030155biological_processregulation of cell adhesion
R0030334biological_processregulation of cell migration
R0030335biological_processpositive regulation of cell migration
R0031252cellular_componentcell leading edge
R0031410cellular_componentcytoplasmic vesicle
R0031625molecular_functionubiquitin protein ligase binding
R0032027molecular_functionmyosin light chain binding
R0032991cellular_componentprotein-containing complex
R0038147molecular_functionC-X-C motif chemokine 12 receptor activity
R0038160biological_processCXCL12-activated CXCR4 signaling pathway
R0043130molecular_functionubiquitin binding
R0043217biological_processmyelin maintenance
R0046718biological_processsymbiont entry into host cell
R0048714biological_processpositive regulation of oligodendrocyte differentiation
R0060326biological_processcell chemotaxis
R0070062cellular_componentextracellular exosome
R0070098biological_processchemokine-mediated signaling pathway
R0070161cellular_componentanchoring junction
R0071345biological_processcellular response to cytokine stimulus
R0120162biological_processpositive regulation of cold-induced thermogenesis
R1904018biological_processpositive regulation of vasculature development
R2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSVlILAFISLDRYLaI
ChainResidueDetails
RSER122-ILE138
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
LTYR197-HIS203
HTYR207-HIS213
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues144
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues200
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues80
DetailsTransmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues12
DetailsRegion: {"description":"Chemokine binding","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10825158","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues16
DetailsRegion: {"description":"Chemokine binding"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues48
DetailsRegion: {"description":"Involved in dimerization; when bound to chemokine"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues16
DetailsRegion: {"description":"Chemokine binding, important for signaling and HIV-1 coreceptor activity"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues84
DetailsRegion: {"description":"Involved in dimerization"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues8
DetailsMotif: {"description":"Important for signaling"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues4
DetailsSite: {"description":"Chemokine binding"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsSite: {"description":"Chemokine binding","evidences":[{"source":"PubMed","id":"20929726","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10825158","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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