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8U4T

Structure of tetrameric CXCR4 in complex with REGN7663 Fab

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
AA0001618molecular_functionvirus receptor activity
AA0001666biological_processresponse to hypoxia
AA0001764biological_processneuron migration
AA0002064biological_processepithelial cell development
AA0002407biological_processdendritic cell chemotaxis
AA0003779molecular_functionactin binding
AA0004930molecular_functionG protein-coupled receptor activity
AA0005515molecular_functionprotein binding
AA0005737cellular_componentcytoplasm
AA0005764cellular_componentlysosome
AA0005768cellular_componentendosome
AA0005769cellular_componentearly endosome
AA0005770cellular_componentlate endosome
AA0005886cellular_componentplasma membrane
AA0006915biological_processapoptotic process
AA0006954biological_processinflammatory response
AA0006955biological_processimmune response
AA0007186biological_processG protein-coupled receptor signaling pathway
AA0007204biological_processpositive regulation of cytosolic calcium ion concentration
AA0007420biological_processbrain development
AA0008038biological_processneuron recognition
AA0009615biological_processresponse to virus
AA0009897cellular_componentexternal side of plasma membrane
AA0009986cellular_componentcell surface
AA0014070biological_processresponse to organic cyclic compound
AA0014823biological_processresponse to activity
AA0015026molecular_functioncoreceptor activity
AA0016477biological_processcell migration
AA0016493molecular_functionC-C chemokine receptor activity
AA0016494molecular_functionC-X-C chemokine receptor activity
AA0019722biological_processcalcium-mediated signaling
AA0019957molecular_functionC-C chemokine binding
AA0022008biological_processneurogenesis
AA0022029biological_processtelencephalon cell migration
AA0030155biological_processregulation of cell adhesion
AA0030335biological_processpositive regulation of cell migration
AA0031252cellular_componentcell leading edge
AA0031410cellular_componentcytoplasmic vesicle
AA0031625molecular_functionubiquitin protein ligase binding
AA0032027molecular_functionmyosin light chain binding
AA0032991cellular_componentprotein-containing complex
AA0035470biological_processpositive regulation of vascular wound healing
AA0036094molecular_functionsmall molecule binding
AA0038147molecular_functionC-X-C motif chemokine 12 receptor activity
AA0038160biological_processCXCL12-activated CXCR4 signaling pathway
AA0043067biological_processregulation of programmed cell death
AA0043130molecular_functionubiquitin binding
AA0043217biological_processmyelin maintenance
AA0045446biological_processendothelial cell differentiation
AA0046718biological_processsymbiont entry into host cell
AA0048714biological_processpositive regulation of oligodendrocyte differentiation
AA0050769biological_processpositive regulation of neurogenesis
AA0050792biological_processregulation of viral process
AA0050920biological_processregulation of chemotaxis
AA0050921biological_processpositive regulation of chemotaxis
AA0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
AA0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
AA0051924biological_processregulation of calcium ion transport
AA0060048biological_processcardiac muscle contraction
AA0060326biological_processcell chemotaxis
AA0061154biological_processendothelial tube morphogenesis
AA0070062cellular_componentextracellular exosome
AA0070098biological_processchemokine-mediated signaling pathway
AA0070161cellular_componentanchoring junction
AA0071345biological_processcellular response to cytokine stimulus
AA0071417biological_processcellular response to organonitrogen compound
AA0071466biological_processcellular response to xenobiotic stimulus
AA0120162biological_processpositive regulation of cold-induced thermogenesis
AA1901327biological_processresponse to tacrolimus
AA1903861biological_processpositive regulation of dendrite extension
AA1904018biological_processpositive regulation of vasculature development
AA1905322biological_processpositive regulation of mesenchymal stem cell migration
AA1990478biological_processresponse to ultrasound
AA2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
I0001618molecular_functionvirus receptor activity
I0001666biological_processresponse to hypoxia
I0001764biological_processneuron migration
I0002064biological_processepithelial cell development
I0002407biological_processdendritic cell chemotaxis
I0003779molecular_functionactin binding
I0004930molecular_functionG protein-coupled receptor activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005764cellular_componentlysosome
I0005768cellular_componentendosome
I0005769cellular_componentearly endosome
I0005770cellular_componentlate endosome
I0005886cellular_componentplasma membrane
I0006915biological_processapoptotic process
I0006954biological_processinflammatory response
I0006955biological_processimmune response
I0007186biological_processG protein-coupled receptor signaling pathway
I0007204biological_processpositive regulation of cytosolic calcium ion concentration
I0007420biological_processbrain development
I0008038biological_processneuron recognition
I0009615biological_processresponse to virus
I0009897cellular_componentexternal side of plasma membrane
I0009986cellular_componentcell surface
I0014070biological_processresponse to organic cyclic compound
I0014823biological_processresponse to activity
I0015026molecular_functioncoreceptor activity
I0016477biological_processcell migration
I0016493molecular_functionC-C chemokine receptor activity
I0016494molecular_functionC-X-C chemokine receptor activity
I0019722biological_processcalcium-mediated signaling
I0019957molecular_functionC-C chemokine binding
I0022008biological_processneurogenesis
I0022029biological_processtelencephalon cell migration
I0030155biological_processregulation of cell adhesion
I0030335biological_processpositive regulation of cell migration
I0031252cellular_componentcell leading edge
I0031410cellular_componentcytoplasmic vesicle
I0031625molecular_functionubiquitin protein ligase binding
I0032027molecular_functionmyosin light chain binding
I0032991cellular_componentprotein-containing complex
I0035470biological_processpositive regulation of vascular wound healing
I0036094molecular_functionsmall molecule binding
I0038147molecular_functionC-X-C motif chemokine 12 receptor activity
I0038160biological_processCXCL12-activated CXCR4 signaling pathway
I0043067biological_processregulation of programmed cell death
I0043130molecular_functionubiquitin binding
I0043217biological_processmyelin maintenance
I0045446biological_processendothelial cell differentiation
I0046718biological_processsymbiont entry into host cell
I0048714biological_processpositive regulation of oligodendrocyte differentiation
I0050769biological_processpositive regulation of neurogenesis
I0050792biological_processregulation of viral process
I0050920biological_processregulation of chemotaxis
I0050921biological_processpositive regulation of chemotaxis
I0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
I0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
I0051924biological_processregulation of calcium ion transport
I0060048biological_processcardiac muscle contraction
I0060326biological_processcell chemotaxis
I0061154biological_processendothelial tube morphogenesis
I0070062cellular_componentextracellular exosome
I0070098biological_processchemokine-mediated signaling pathway
I0070161cellular_componentanchoring junction
I0071345biological_processcellular response to cytokine stimulus
I0071417biological_processcellular response to organonitrogen compound
I0071466biological_processcellular response to xenobiotic stimulus
I0120162biological_processpositive regulation of cold-induced thermogenesis
I1901327biological_processresponse to tacrolimus
I1903861biological_processpositive regulation of dendrite extension
I1904018biological_processpositive regulation of vasculature development
I1905322biological_processpositive regulation of mesenchymal stem cell migration
I1990478biological_processresponse to ultrasound
I2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
Q0001618molecular_functionvirus receptor activity
Q0001666biological_processresponse to hypoxia
Q0001764biological_processneuron migration
Q0002064biological_processepithelial cell development
Q0002407biological_processdendritic cell chemotaxis
Q0003779molecular_functionactin binding
Q0004930molecular_functionG protein-coupled receptor activity
Q0005515molecular_functionprotein binding
Q0005737cellular_componentcytoplasm
Q0005764cellular_componentlysosome
Q0005768cellular_componentendosome
Q0005769cellular_componentearly endosome
Q0005770cellular_componentlate endosome
Q0005886cellular_componentplasma membrane
Q0006915biological_processapoptotic process
Q0006954biological_processinflammatory response
Q0006955biological_processimmune response
Q0007186biological_processG protein-coupled receptor signaling pathway
Q0007204biological_processpositive regulation of cytosolic calcium ion concentration
Q0007420biological_processbrain development
Q0008038biological_processneuron recognition
Q0009615biological_processresponse to virus
Q0009897cellular_componentexternal side of plasma membrane
Q0009986cellular_componentcell surface
Q0014070biological_processresponse to organic cyclic compound
Q0014823biological_processresponse to activity
Q0015026molecular_functioncoreceptor activity
Q0016477biological_processcell migration
Q0016493molecular_functionC-C chemokine receptor activity
Q0016494molecular_functionC-X-C chemokine receptor activity
Q0019722biological_processcalcium-mediated signaling
Q0019957molecular_functionC-C chemokine binding
Q0022008biological_processneurogenesis
Q0022029biological_processtelencephalon cell migration
Q0030155biological_processregulation of cell adhesion
Q0030335biological_processpositive regulation of cell migration
Q0031252cellular_componentcell leading edge
Q0031410cellular_componentcytoplasmic vesicle
Q0031625molecular_functionubiquitin protein ligase binding
Q0032027molecular_functionmyosin light chain binding
Q0032991cellular_componentprotein-containing complex
Q0035470biological_processpositive regulation of vascular wound healing
Q0036094molecular_functionsmall molecule binding
Q0038147molecular_functionC-X-C motif chemokine 12 receptor activity
Q0038160biological_processCXCL12-activated CXCR4 signaling pathway
Q0043067biological_processregulation of programmed cell death
Q0043130molecular_functionubiquitin binding
Q0043217biological_processmyelin maintenance
Q0045446biological_processendothelial cell differentiation
Q0046718biological_processsymbiont entry into host cell
Q0048714biological_processpositive regulation of oligodendrocyte differentiation
Q0050769biological_processpositive regulation of neurogenesis
Q0050792biological_processregulation of viral process
Q0050920biological_processregulation of chemotaxis
Q0050921biological_processpositive regulation of chemotaxis
Q0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
Q0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
Q0051924biological_processregulation of calcium ion transport
Q0060048biological_processcardiac muscle contraction
Q0060326biological_processcell chemotaxis
Q0061154biological_processendothelial tube morphogenesis
Q0070062cellular_componentextracellular exosome
Q0070098biological_processchemokine-mediated signaling pathway
Q0070161cellular_componentanchoring junction
Q0071345biological_processcellular response to cytokine stimulus
Q0071417biological_processcellular response to organonitrogen compound
Q0071466biological_processcellular response to xenobiotic stimulus
Q0120162biological_processpositive regulation of cold-induced thermogenesis
Q1901327biological_processresponse to tacrolimus
Q1903861biological_processpositive regulation of dendrite extension
Q1904018biological_processpositive regulation of vasculature development
Q1905322biological_processpositive regulation of mesenchymal stem cell migration
Q1990478biological_processresponse to ultrasound
Q2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
R0001618molecular_functionvirus receptor activity
R0001666biological_processresponse to hypoxia
R0001764biological_processneuron migration
R0002064biological_processepithelial cell development
R0002407biological_processdendritic cell chemotaxis
R0003779molecular_functionactin binding
R0004930molecular_functionG protein-coupled receptor activity
R0005515molecular_functionprotein binding
R0005737cellular_componentcytoplasm
R0005764cellular_componentlysosome
R0005768cellular_componentendosome
R0005769cellular_componentearly endosome
R0005770cellular_componentlate endosome
R0005886cellular_componentplasma membrane
R0006915biological_processapoptotic process
R0006954biological_processinflammatory response
R0006955biological_processimmune response
R0007186biological_processG protein-coupled receptor signaling pathway
R0007204biological_processpositive regulation of cytosolic calcium ion concentration
R0007420biological_processbrain development
R0008038biological_processneuron recognition
R0009615biological_processresponse to virus
R0009897cellular_componentexternal side of plasma membrane
R0009986cellular_componentcell surface
R0014070biological_processresponse to organic cyclic compound
R0014823biological_processresponse to activity
R0015026molecular_functioncoreceptor activity
R0016477biological_processcell migration
R0016493molecular_functionC-C chemokine receptor activity
R0016494molecular_functionC-X-C chemokine receptor activity
R0019722biological_processcalcium-mediated signaling
R0019957molecular_functionC-C chemokine binding
R0022008biological_processneurogenesis
R0022029biological_processtelencephalon cell migration
R0030155biological_processregulation of cell adhesion
R0030335biological_processpositive regulation of cell migration
R0031252cellular_componentcell leading edge
R0031410cellular_componentcytoplasmic vesicle
R0031625molecular_functionubiquitin protein ligase binding
R0032027molecular_functionmyosin light chain binding
R0032991cellular_componentprotein-containing complex
R0035470biological_processpositive regulation of vascular wound healing
R0036094molecular_functionsmall molecule binding
R0038147molecular_functionC-X-C motif chemokine 12 receptor activity
R0038160biological_processCXCL12-activated CXCR4 signaling pathway
R0043067biological_processregulation of programmed cell death
R0043130molecular_functionubiquitin binding
R0043217biological_processmyelin maintenance
R0045446biological_processendothelial cell differentiation
R0046718biological_processsymbiont entry into host cell
R0048714biological_processpositive regulation of oligodendrocyte differentiation
R0050769biological_processpositive regulation of neurogenesis
R0050792biological_processregulation of viral process
R0050920biological_processregulation of chemotaxis
R0050921biological_processpositive regulation of chemotaxis
R0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
R0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
R0051924biological_processregulation of calcium ion transport
R0060048biological_processcardiac muscle contraction
R0060326biological_processcell chemotaxis
R0061154biological_processendothelial tube morphogenesis
R0070062cellular_componentextracellular exosome
R0070098biological_processchemokine-mediated signaling pathway
R0070161cellular_componentanchoring junction
R0071345biological_processcellular response to cytokine stimulus
R0071417biological_processcellular response to organonitrogen compound
R0071466biological_processcellular response to xenobiotic stimulus
R0120162biological_processpositive regulation of cold-induced thermogenesis
R1901327biological_processresponse to tacrolimus
R1903861biological_processpositive regulation of dendrite extension
R1904018biological_processpositive regulation of vasculature development
R1905322biological_processpositive regulation of mesenchymal stem cell migration
R1990478biological_processresponse to ultrasound
R2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. SSVlILAFISLDRYLaI
ChainResidueDetails
RSER122-ILE138

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
LTYR197-HIS203
HTYR207-HIS213

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues96
DetailsTRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:20929726
ChainResidueDetails
RILE39-MET63
IILE39-MET63
QILE39-MET63
AAILE39-MET63

site_idSWS_FT_FI2
Number of Residues436
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:20929726
ChainResidueDetails
RGLY64-ARG77
QSER131-LYS154
QSER217-THR241
QALA303-SER352
AAGLY64-ARG77
AASER131-LYS154
AASER217-THR241
AAALA303-SER352
RSER131-LYS154
RSER217-THR241
RALA303-SER352
IGLY64-ARG77
ISER131-LYS154
ISER217-THR241
IALA303-SER352
QGLY64-ARG77

site_idSWS_FT_FI3
Number of Residues84
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:20929726
ChainResidueDetails
RLEU78-VAL99
ILEU78-VAL99
QLEU78-VAL99
AALEU78-VAL99

site_idSWS_FT_FI4
Number of Residues200
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:20929726
ChainResidueDetails
RALA100-LYS110
AAALA100-LYS110
AAALA175-TRP195
AAASP262-LYS282
RALA175-TRP195
RASP262-LYS282
IALA100-LYS110
IALA175-TRP195
IASP262-LYS282
QALA100-LYS110
QALA175-TRP195
QASP262-LYS282

site_idSWS_FT_FI5
Number of Residues76
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:20929726
ChainResidueDetails
RALA111-ILE130
IALA111-ILE130
QALA111-ILE130
AAALA111-ILE130

site_idSWS_FT_FI6
Number of Residues76
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:20929726
ChainResidueDetails
RVAL155-PHE174
IVAL155-PHE174
QVAL155-PHE174
AAVAL155-PHE174

site_idSWS_FT_FI7
Number of Residues80
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:20929726
ChainResidueDetails
RVAL196-LEU216
IVAL196-LEU216
QVAL196-LEU216
AAVAL196-LEU216

site_idSWS_FT_FI8
Number of Residues76
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:20929726
ChainResidueDetails
RVAL242-ILE261
IVAL242-ILE261
QVAL242-ILE261
AAVAL242-ILE261

site_idSWS_FT_FI9
Number of Residues76
DetailsTRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:20929726
ChainResidueDetails
RTRP283-TYR302
ITRP283-TYR302
QTRP283-TYR302
AATRP283-TYR302

site_idSWS_FT_FI10
Number of Residues4
DetailsSITE: Chemokine binding
ChainResidueDetails
RASP171
IASP171
QASP171
AAASP171

site_idSWS_FT_FI11
Number of Residues4
DetailsSITE: Chemokine binding => ECO:0000269|PubMed:20929726, ECO:0000305|PubMed:10825158
ChainResidueDetails
RGLU288
IGLU288
QGLU288
AAGLU288

site_idSWS_FT_FI12
Number of Residues8
DetailsMOD_RES: Sulfotyrosine; partial => ECO:0000269|PubMed:18834145
ChainResidueDetails
RTYR7
RTYR12
ITYR7
ITYR12
QTYR7
QTYR12
AATYR7
AATYR12

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: Sulfotyrosine => ECO:0000269|PubMed:12034737, ECO:0000269|PubMed:16725153, ECO:0000269|PubMed:18834145
ChainResidueDetails
RTYR21
ITYR21
QTYR21
AATYR21

site_idSWS_FT_FI14
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
RSER319
RSER348
ISER319
ISER348
QSER319
QSER348
AASER319
AASER348

site_idSWS_FT_FI15
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:20048153, ECO:0007744|PubMed:23186163
ChainResidueDetails
RSER321
ISER321
QSER321
AASER321

site_idSWS_FT_FI16
Number of Residues8
DetailsMOD_RES: Phosphoserine; by PKC and GRK6 => ECO:0000269|PubMed:19116316, ECO:0000269|PubMed:20048153, ECO:0007744|PubMed:23186163
ChainResidueDetails
RSER324
RSER325
ISER324
ISER325
QSER324
QSER325
AASER324
AASER325

site_idSWS_FT_FI17
Number of Residues8
DetailsMOD_RES: Phosphoserine; by GRK6 => ECO:0000269|PubMed:20048153
ChainResidueDetails
RSER330
RSER339
ISER330
ISER339
QSER330
QSER339
AASER330
AASER339

site_idSWS_FT_FI18
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:20048153
ChainResidueDetails
RSER351
ISER351
QSER351
AASER351

site_idSWS_FT_FI19
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10756055
ChainResidueDetails
RASN11
IASN11
QASN11
AAASN11

site_idSWS_FT_FI20
Number of Residues4
DetailsCARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine => ECO:0000269|PubMed:12034737
ChainResidueDetails
RSER18
ISER18
QSER18
AASER18

site_idSWS_FT_FI21
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
RASN176
IASN176
QASN176
AAASN176

site_idSWS_FT_FI22
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:28978524
ChainResidueDetails
RLYS331
ILYS331
QLYS331
AALYS331

221716

PDB entries from 2024-06-26

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