6GMX
pVHL:EloB:EloC in complex with 6-chlorothiochroman-4-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, G, J | Elongin-B | polymer | 104 | 11956.4 | 3 | UniProt (Q15370) Pfam (PF00240) In PDB | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 2 | B, H, K | Elongin-C | polymer | 97 | 10974.6 | 3 | UniProt (Q15369) Pfam (PF03931) In PDB | Homo sapiens (Human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 3 | C, F, I, L | von Hippel-Lindau disease tumor suppressor | polymer | 162 | 18806.3 | 4 | UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB | Homo sapiens (Human) | Protein G7,pVHL |
| 4 | D | Elongin-B | polymer | 104 | 11852.4 | 1 | UniProt (Q15370) Pfam (PF00240) In PDB | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 5 | E | Elongin-C | polymer | 97 | 11078.6 | 1 | UniProt (Q15369) Pfam (PF03931) In PDB | Homo sapiens (Human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 6 | B, K | 6-chloranyl-2,3-dihydrothiochromen-4-one | non-polymer | 198.7 | 2 | Chemie (F7B) | |||
| 7 | C, F, I, L | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 4 | Chemie (IPA) | |||
| 8 | F, L | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 9 | water | water | 18.0 | 355 | Chemie (HOH) |
Sequence modifications
B, H, K: 17 - 112 (UniProt: Q15369)
C, F, I, L: 54 - 213 (UniProt: P40337)
E: 17 - 111 (UniProt: Q15369)
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly 52 | - | expression tag |
| Ser 53 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
| Cas 112 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 166949.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 755.8 | |
| All* | Total formula weight | 167704.9 |
