6GMX

pVHL:EloB:EloC in complex with 6-chlorothiochroman-4-one

Summary for 6GMX

Entry DOI	10.2210/pdb6gmx/pdb
Descriptor	Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (9 entities in total)
Functional Keywords	e3 ubiquitin ligase, tumor supressor, protac, fragment-based drug discovery, oncoprotein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	167704.85
Authors	Van Molle, I.,Lucas, X.,Ciulli, A. (deposition date: 2018-05-28, release date: 2018-08-08, Last modification date: 2018-09-05)
Primary citation	Lucas, X.,Van Molle, I.,Ciulli, A. Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J. Med. Chem., 61:7387-7393, 2018 Cited by PubMed: 30040896 DOI: 10.1021/acs.jmedchem.8b00842 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.533 Å)

Structure validation