6GMX
pVHL:EloB:EloC in complex with 6-chlorothiochroman-4-one
Summary for 6GMX
Entry DOI | 10.2210/pdb6gmx/pdb |
Descriptor | Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... (9 entities in total) |
Functional Keywords | e3 ubiquitin ligase, tumor supressor, protac, fragment-based drug discovery, oncoprotein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 12 |
Total formula weight | 167704.85 |
Authors | Van Molle, I.,Lucas, X.,Ciulli, A. (deposition date: 2018-05-28, release date: 2018-08-08, Last modification date: 2018-09-05) |
Primary citation | Lucas, X.,Van Molle, I.,Ciulli, A. Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase. J. Med. Chem., 61:7387-7393, 2018 Cited by PubMed: 30040896DOI: 10.1021/acs.jmedchem.8b00842 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.533 Å) |
Structure validation
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