1XFA
Structure of NBD1 from murine CFTR- F508R mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cystic fibrosis transmembrane conductance regulator | polymer | 283 | 31779.0 | 2 | UniProt (P26361) Pfam (PF00005) | Mus musculus (house mouse) | CFTR, cAMP-dependent chloride channel |
| 2 | C, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, E (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | F, J (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | G, H, K, L (A, B) | ACETIC ACID | non-polymer | 60.1 | 4 | Chemie (ACY) |
Sequence modifications
A, B: 388 - 670 (UniProt: P26361)
| PDB | External Database | Details |
|---|---|---|
| Ser 388 | Met 388 | cloning artifact |
| Arg 508 | Phe 508 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63558.1 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1374.1 | |
| All* | Total formula weight | 64932.2 |
