1XFA

Structure of NBD1 from murine CFTR- F508R mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity
B	0005524	molecular_function	ATP binding
B	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 3

Chain	Residue
A	ATP1
A	THR465
A	GLN493

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 4

Chain	Residue
B	ATP2
B	THR465
B	GLN493
B	ASP572

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CL A 5

Chain	Residue
A	GLY550
A	ARG553
B	VAL546
B	THR547
B	LEU548
A	LEU548
A	SER549

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 6

Chain	Residue
A	VAL546
A	THR547
A	LEU548
B	LEU548
B	GLY550
B	ARG553

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ATP A 1

Chain	Residue
A	MG3
A	TRP401
A	LEU433
A	ASN438
A	PRO439
A	GLY461
A	SER462
A	GLY463
A	LYS464
A	THR465
A	SER466
A	GLN493
B	MET498
B	ARG508

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ATP B 2

Chain	Residue
B	MG4
B	TRP401
B	GLY461
B	SER462
B	GLY463
B	LYS464
B	THR465
B	SER466
B	GLN493

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY A 7

Chain	Residue
A	LEU541
A	GLY542
A	GLY545
A	VAL546
A	THR547

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY B 8

Chain	Residue
B	LEU541
B	GLY542
B	GLY545
B	VAL546
B	THR547

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACY A 9

Chain	Residue
A	LYS532
A	SER549
B	LYS532
B	GLN552

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACY B 10

Chain	Residue
B	GLY451
B	ALA596

---

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRARISLARAV

Chain	Residue	Details
A	LEU548-VAL562

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P13569","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"1Q3H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R0X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R0Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R10","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SI7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"1Q3H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R0X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R0Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XFA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P13569","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"UniProtKB","id":"P13569","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"P13569","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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